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Ziprasidone for pediatric bipolar disorder.(Case Report)
# Patients: 3 males, 1 female; age range, 7 to 16 years old Medication: ziprasidone (Geodon)
Comments: Four children with bipolar disorder were switched to ziprasidone from mood stabilizers, anticonvulsants, or other atypical antipsychotics for reasons including suboptimal efficacy or tolerability problems. In order to manage potential sedation (evening dosing) or wakefulness (morning dosing), a two-week induction protocol with gradual dose escalation to optimal doses (40 mg/day for children; 60 mg/day for adolescents) was employed. Patients experiencing sedation or wakefulness at dose escalation were maintained at a 20- or 40-mg dose level until side effects …
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