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CpG-containing oligodeoxynucleotides increase adjuvant effects.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- CpG-containing oligodeoxynucleotides increased effects of immunological adjuvants in rabbits.
According to published research from Canada, "The efficacy of oligodeoxymicleotides containing unmethylated CpG dinucleotides (CpG ODN) as an adjuvant for rabbits was assessed alone and in combination with aluminum hydroxide (CpG/alum). The CpG/alum combination elicited a greater immune response to several antigens compared to Freund's adjuvant. A non-CpG/alum combination did not have the same effects as CpG/alum suggesting that the adjuvanticity was related to the CpG motifs."
"In addition, we formulated one of the antigens with combinations of CpG ODN and 30 or 10% Emulsigen (Em) [CpG/Em (30%) and CpG/Em (10%)]," reported Xenia P. Ioannou and colleagues at the Veterinary Infectious Disease Organization in Saskatoon. "Both CpG/Em (30%) and CpG/Em (10%) were more effective than Em, and equivalent to CpG/alum. The CpG/Em (10%) combination caused minimal tissue damage. Our results demonstrate ...
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- Newspaper article from: Vaccine Weekly January 22, 2003 700+ words
...pulsed DC or peritumoral injections of CpG ODN, both effective for the treatment...strongly increased by coinjection of CpG ODN, resulting in a transient control...injection of antigen-pulsed DC plus CpG ODN at a site distant to the tumor with...
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...pulsed DC or peritumoral injections of CpG ODN, both effective for the treatment...strongly increased by coinjection of CpG ODN, resulting in a transient control...injection of antigen-pulsed DC plus CpG ODN at a site distant to the tumor with...
- Study: Remune antigen with CpG ODN may offer HIV protection.(Brief Article)
- Newspaper article from: AIDS Weekly December 16, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses...results suggest that Remune antigen plus CpG ODN when given as a intranasal immunization...Remune antigen in combination with CpG ODN. Mice immunized with Remune antigen...
- Study: Remune antigen with CpG ODN may offer HIV protection.
- Newspaper article from: Vaccine Weekly December 18, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses...results suggest that Remune antigen plus CpG ODN when given as a intranasal immunization...Remune antigen in combination with CpG ODN. Mice immunized with Remune antigen...
- Trypanosoma cruzi antigen and CpG-ODN protect against trypomastigotes.
- Newspaper article from: Health & Medicine Week April 26, 2004 700+ words
...oligodeoxynucleotides containing CpG-motifs (CpG-ODN) are capable of driving immunity...ability of Ag163B6/cruzipain plus CpG-ODN to induce immunoprotection against...Mice were immunized with Ag163B6 + CpG-ODN showing high specific antibody titers...
- The Immune Response Corporation Announces Study Suggesting Protection From HIV...
- Press release article from: PR Newswire October 17, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses...suggest that REMUNE(R) antigen plus CpG ODN when given as a intranasal immunization...R) antigen in combination with CpG ODN. Mice immunized with REMUNE(R...
- The Immune Response Corp announces study suggesting protection from HIV...
- News wire article from: Asia Africa Intelligence Wire October 17, 2002 700+ words
...containing immunostimulatory CpG motifs (CpG ODN) induces HIV-specific immune responses...Remune antigen in combination with CpG ODN. Mice immunized with Remune antigen plus CpG ODN had enhanced levels of anti-p24...
- CpG ODN properties might be useful in developing immunotherapy adjuvants.
- Newspaper article from: Immunotherapy Weekly January 22, 2003 700+ words
...be because IFN-gamma, induced by CpG ODNs, is also inhibited by IL-10...of IFN-gamma was downregulated by CpG ODN-induced IL-10 via modulation of...concluded that their "data suggest that CpG ODNs may inhibit established Th2 immune...
- CpG-DNA derived from sera in systemic lupus erythematosus enhances ICAM-1...
- Magazine article from: Annals of the Rheumatic Diseases Miyata, M Ito, O Kobayashi, H Sasajima, T Ohira, H Suzuki, S Kasukawa, R July 1, 2001 700+ words
...ODNs) containing a CpG motif (CpG-ODN), of which the sequence was derived...endothelial cells (EC). Methods--A CpG-ODN or a control analogue, GpC-ODN...chain reaction. Results--The CpG-ODN augmented the expression of ICAM...
- Combining dendritic cells and CpG oligodeoxynucleotides cures colon cancer in...
- Newspaper article from: Vaccine Weekly February 5, 2003 700+ words
...and CpG oligodeoxynucleotides (CpG ODN), according to a report in the European...of either antigen-pulsed DCs or CpG ODN, while effective against small...injection of antigen-pulsed DC plus CpG ODN at a site distant to the tumor with...
Source: HighBeam Research, CpG-containing oligodeoxynucleotides increase adjuvant effects.