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Gastrointestinal functions of proteinase-activated receptors reviewed.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- A researcher reviews the gastrointestinal functions of proteinase-activated receptors in a recent issue of the journal Life Sciences.
According to a study from Japan, "Proteinase-activated receptors (PARs) are a family of G-protein-coupled-seven-trans-membrane-domain receptors, consisting of four family members. PARs, especially PAR-1, a thrombin receptor, and PAR-2, a receptor for trypsin, tryptase, and coagulation factors VIIa and Xa, are abundantly distributed throughout the gastrointestinal tract. PAR-2, but not other PARs, induces salivary and pancreatic exocrine secretion."
"Both PAR-2 and PAR-1 play protective roles in the gastric mucosa, modulating a variety of gastric functions," said Atsufumi Kawabata at Kinki University. "However, the mechanisms underlying the mucosal protection caused by PAR-2 and PAR-1 are entirely different. In the intestinal mucosa, PAR-2 appears to play a dual role, being pro- and anti-inflammatory. PAR-1, PAR-2 and also PAR-4 modulate the motility of the smooth muscle in ...
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...modulating phosphorylation of Par-6 in Drosophila neuroblast...divisions,' new data in life sciences. "Drosophila neural...aPKC), Bazooka (Par-3) and Par-6, organizes cell...Japan report (see also Life Sciences). "Aurora-A (AurA...
- Data on life sciences detailed by researchers at University of Cambridge,...
- Newspaper article from: Science Letter August 26, 2008 700+ words
...A casein kinase 1 and PAR proteins regulate asymmetry...positioning,' new data in life sciences. According to recent...division. The conserved PAR proteins together with...Institute (see also Life Sciences). The researchers concluded...A casein kinase 1 and PAR proteins ...
- Research on life sciences detailed by scientists at University College,...
- Newspaper article from: Biotech Week July 15, 2009 700+ words
...Kingdom report (see also Life Sciences). "In hearing dyslexics...gyrus. This includes the pars triangularis, extending...posterior portion of the pars triangularis extending into the ventral pars opercularis, was activated...United Kingdom, London, Life Sciences, Cognitive ...
- New life sciences study results reported from University of Wyoming.
- Newspaper article from: Biotech Week February 18, 2009 700+ words
...immunoreactive cells in the ovine pars tuberalis,' new data in life sciences. "The pars tuberalis (PT) is a distinct...States report (see also Life Sciences). "The identity of this...SP). Few cells in the pars distalis immunoreact for...
- Findings from Ovchinnikov Institute of Bioorganic Chemistry advance knowledge...
- Newspaper article from: Science Letter August 26, 2008 700+ words
...nucleases' new findings in life sciences. According to a study...specific nuclease (Par_DSN) has been classified...active site composition of Par_DSN is similar but...Chemistry (see also Life Sciences). The researchers concluded...new classification of Par_DSN-like nucleases...
- Yokohama City University, Department of Molecular Biology details research in...
- Newspaper article from: Science Letter July 21, 2009 700+ words
...contacts provide spatial cues that activate the aPKC-PAR-3-PAR-6 complex to establish the landmark of the initial...scientists in Yokohama, Japan report (see also Life Sciences). "PAR-1, a downstream target of the aPKC-PAR-3...
- New data from Research Center illuminate research in life sciences.(Report)
- Newspaper article from: Diabetes Week November 10, 2008 700+ words
A report, 'PAR-5359, a well-balanced PPARalpha...the pharmacological profiles of PAR-5359, a dual agonist of PPARalpha...researchers in Korea report (see also Life Sciences). "In transient transactivation assay, PAR-5359 (3-(4-(2[4...
- Recent findings in life sciences described by F. Carletti and colleagues.
- Newspaper article from: Biotech Week June 10, 2009 700+ words
...discharge of substantia nigra pars reticulata neurons...the rat,' new data in life sciences. According to recent...activity of neurons of the pars reticulata of the substantia...colleagues, (see also Life Sciences). The researchers concluded...discharge of substantia nigra ...