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Aggregate content influences Thl/Th2 response to influenza vaccine.
Vaccine Weekly
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January 21, 2004 |
COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Aggregate content influences the Thl/Th2 immune response to the influenza vaccine.
"During the 2000-2001 season, a newly identified oculo-respiratory syndrome (ORS) was detected across Canada as an adverse effect to one influenza vaccine. The implicated vaccine contained a higher than expected proportion of unsplit and aggregated influenza virions. Clinical and epidemiologic features of ORS were suggestive of type 2-like influences on the immune response," researchers in Canada report.
"We hypothesized that the implicated vaccine from the 2000-2001 season would induce greater Th2-like polarization relative to the non-implicated vaccine from the same season," said Shawn Babiuk at the Vaccine and Infectious Disease Organization in Saskatoon and collaborators in Canada. "Three groups consisting of eight mice each were either immunized with implicated vaccine, immunized with non-implicated vaccine or not immunized. Antigen-specific cellular responses were characterized based on the balance of Th2 (IL-4, IL-5) and Th1 (IFN-gamma) ...
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Source: HighBeam Research, Aggregate content influences Thl/Th2 response to influenza vaccine.