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Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity.
"Heat shock proteins (HSPs) are recognized as significant participants in immune reactions. We previously reported that expression of HSP70 in response to hyperthermia, produced using our original magnetite cationic liposomes (MCLs), induces antitumor immunity. In the present study, we examine whether the antitumor immunity induced by hyperthermia is enhanced by hsp70 gene transfer," researchers in Japan report.
"A human hsp70 gene mediated by cationic liposomes was injected into a B16 melanoma nodule in C57BL/6 mice in situ. At 24 hours after the injection of the hsp70 gene, MCLs were injected into melanoma nodules in C57BL/6 mice, which were subjected to an alternating magnetic field for 30 minutes," described A. Ito and colleagues, Nagoya University, School of Engineering.
"The temperature at the tumor reached 43 degrees C and was maintained by controlling the magnetic field intensity. The combined treatment strongly arrested tumor growth over a 30-day period, and complete ...
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Source: HighBeam Research, Heat shock protein 70 gene therapy and hyperthermia boost antitumor...