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Candidate HIV-1 subtype C DNA vaccine for South Africa characterized.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Researchers have constructed and characterized a candidate HIV-1 subtype C DNA vaccine for South Africa.
"A candidate DNA vaccine pTHgagC expressing the immunodeficiency virus-1 (HIV-1) gag gene from South African isolate Du422 was constructed and characterized. The isolate was selected on the basis of being the closest to the South African subtype C consensus sequence. Sequence analysis of cytotoxic T lymphocyte (CTL) epitopes showed that HIV subtype C-infected individuals have CTL responses to a number of epitopes present in the vaccine, but also revealed a more limited presence of subtype A- and any B-derived epitopes," investigators in South Africa report.
"A high level of expression of the immunogen was demonstrated in human cells and a potent, long-lived CTL response to a single inoculation of the DNA vaccine was elicited in BALB/c mice, which could be significantly increased by a boost vaccination at four weeks," said Joanne H. van Harmelen and collaborators at the University of Cape Town in South Africa and the Weatherall Institute of Molecular Medicine in ...
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Source: HighBeam Research, Candidate HIV-1 subtype C DNA vaccine for South Africa characterized.