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Plasmid DNA activates dendritic cells via toll-like receptor 9.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Vaccination with plasmid DNA activates dendritic cells via toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice.
"We analyzed whether the immunobiology of vaccinating plasmid DNA containing a transcription unit for OVA is influenced by immunostimulatory CpG motifs in the plasmid backbone. Indeed, plasmid DNA differentially activated in vitro myeloid and plasmacytoid dendritic cells (DCs) provided they expressed the CpG-DNA receptor, Toll-like receptor 9 (TLR9). Dependent on the DC subset, activation resulted in type 1 IFN production, while both DC subsets produced IL-6 and up-regulated expression of costimulatory molecules CD40 and CD86," scientists writing in the Journal of Immunology report.
"In vivo, however, even upon repeated vaccination with plasmid DNA, priming of OVA-specific CTL and clonal expansion of SIINFEKL-specific CD8 T cells were equal in TLR9-positive and TLR9- or MyD88-negative mice," stated Barbara Spies and colleagues at the Technical ...
- Plasmid DNA activates dendritic cells via toll-like receptor 9.
- Newspaper article from: Biotech Week January 21, 2004 700+ words
...Vaccination with plasmid DNA activates dendritic cells via toll-like...backbone. Indeed, plasmid DNA differentially...plasmacytoid dendritic cells (DCs) provided...Vaccination with plasmid DNA activates dendritic cells via toll-like...
- Research elucidates role of dendritic cells in relation to plasmid DNA.
- Newspaper article from: Immunotherapy Weekly February 12, 2003 700+ words
...the important roles of dendritic cells in DNA-based therapies...uptake mechanism of plasmid DNA (pDNA) in dendritic cells is poorly understood...rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism...
- Pharmacokinetics Optimization of Targeted Delivery of Plasmid DNA In Vivo.
- Newspaper article from: Gene Therapy Weekly November 23, 1998 700+ words
...pharmacokinetic properties of a plasmid DNA/carrier complex allows in vivo receptor-mediated targeting of plasmid DNA to hepatocytes. M. Nishikawa and...a method of targeted delivery of plasmid DNA to hepatocytes in vivo ("Targeted...
- Cancer Immunotherapy Intratumor IL-2 Plasmid DNA Injection Induces Immunity.
- Newspaper article from: Gene Therapy Weekly December 7, 1998 700+ words
...injection of interleukin-2 (IL-2) plasmid DNA induced CD8(+) T cell immunity in...gene-mediated immunotherapy using a plasmid DNA vector to deliver IL-2 in a murine...Intratumoral Injection of Interleukin-2 Plasmid DNA: Induction of CD8(+) T Cell Immunity...
- Erythrocyte ghosts prolong plasmid DNA expression in the blood.
- Newspaper article from: Biotech Week April 7, 2004 700+ words
...net) -- Erythrocyte ghosts prolong plasmid DNA expression in the blood. According...circulation and prolonged expression of plasmid DNA in the blood. Murine interleukin-2-expressing plasmid DNA was efficiently loaded to EG by electroporation...
- Co-Encapsulation of Antigen and Plasmid DNA Improves Response.
- Newspaper article from: Immunotherapy Weekly April 2, 2000 700+ words
...encapsulation of protein antigen with plasmid DNA antigen improves the immune response...United Kingdom reported. "The use of plasmid DNA in vaccine technology is currently a...Aston University, United Kingdom. "Plasmid DNA has been shown to express antigen in...
- Co-Encapsulation of Antigen and Plasmid DNA Improves Response.(Brief Article)
- Newspaper article from: Gene Therapy Weekly March 30, 2000 700+ words
...encapsulation of protein antigen with plasmid DNA antigen improves the immune response...United Kingdom reported. "The use of plasmid DNA in vaccine technology is currently a...Aston University, United Kingdom. "Plasmid DNA has been shown to express antigen in...
- Cationic polymers afford plasmid DNA protection from ultrasound exposure.
- Newspaper article from: Drug Week July 4, 2003 700+ words
...net) -- Cationic polymers afford plasmid DNA protection from ultrasound exposure...ultrasound exposure, the stability of plasmid DNA protected by polymer-based gene delivery...effectiveness of various polymer-based plasmid DNA delivery systems, which are interactive...
