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Uptake of polioviral RNA creates antigen by neosynthesis, specific CTL result.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Polioviral RNA can be taken up and an antigen for presentation made by neosynthesis, resulting in antigen-specific cytotoxic lymphocyte production, in an animal model.
According to recent research from Switzerland, "induction of antiviral cytotoxic T lymphocytes (CTLs) has been proposed to require cross-presentation of viral antigens derived from infected extralymphatic host cells by antigen-presenting cells (APC).
"This postulated mechanism of crosspriming is thought to be essential for CTL responses against viruses that do not infect professional APC, e.g., because of absence of the specific virus receptor.
"Here we show for the human pathogen poliovirus, that naturally nonpermissive murine APC acquire viral RNA in vivo independently of the cellular virus receptor. Uptake of poliovirus or polioviral RNA initiated neosynthesis of viral antigen to an extent sufficient to prime CTLs in vivo, which were detectable 2-3 wk after infection," wrote S. Freigang and colleagues.
The researchers concluded: "Our results do not only indicate that experiments studying crosspresentation and crosspriming by using ...
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