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recA deletion mutant of M. bovis BCG confers protection.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stability.
"The widely used vaccine against tuberculosis, BCG, shows evidence of genetic instability. It has undergone major genetic rearrangements resulting in deletion and duplication of segments of its chromosome. In order to produce a BCG strain with more favorable genetic properties, we inactivated the recA gene," scientists in Switzerland report.
"Targeted deletion of the recA gene of BCG resulted in a complete loss of recombination between homologous, chromosomally-located sequences, as well as between plasmid- and chromosomally-located sequences," stated Peter Sander and collaborators at the University of Zurich in Switzerland and the National Institute for Medical Research in England. "The Delta-recA mutant BCG was as effective as the wild-type in conferring protection in mice against an intravenous challenge with virulent Mycobacterium tuberculosis, indicating that the loss of an SOS response-mediated DNA repair mechanism did not compromise ...
- BASF.(Jan Peter Sander appointed as head of business )(Brief Article)
- Magazine article from: Nonwovens Industry October 1, 2005 700+ words
As of September 1, 2005, Jan-Peter Sander is the new head of BASF's adhesive and construction industry business in Europe. He succeeds Ralph Schweens, who now leads...
- Also at BASF. Jan-Peter Sander has become head of adhesive and construction...
- Magazine article from: Chemistry and Industry October 3, 2005 700+ words
Also at BASF. Jan-Peter Sander has become head of adhesive and construction industry business in Europe. He takes over from Ralph Schweens who has become head of global marketing Cooordination for polyurethanes.
- Controversy brews over association exec's forgery; NADA bonus checks at heart...
- Magazine article from: Automotive News Harris, Donna February 23, 2004 700+ words
Byline: Donna Harris Peter Sander, CEO of the Illinois Automobile Dealers Association, acknowledges forging signatures to collect bonuses from the National Automobile...
- European adhesive and construction industry business under new leadership.
- Press release article from: M2 Presswire September 12, 2005 700+ words
...12092005 As of September 1, 2005, Jan-Peter Sander is the new head of BASFs adhesive and...headquartered in Ludwigshafen. Jan-Peter Sander is taking over a business segment in...the success of our customers. Jan-Peter Sander has been successfully involved in businesses...
- Lake Zurich is a top town for families Frommer's puts village on top 100 list...
- Newspaper article from: Daily Herald (Arlington Heights, IL) Krishnamurthy, Madhu May 20, 2006 700+ words
...through town five years ago researching the book. He and co-author Peter Sander looked at about 25,000 communities in the U.S. What Sperling liked...Frommer's "Best Places to Raise Your Family" by Bert Sperling and Peter Sander
- Cities Ranked & Rated Declares a Surprising List of Top U.S. Cities to Live in.
- Press release article from: PR Newswire May 7, 2007 700+ words
...850 pages; $24.99), written by Bert Sperling and Peter Sander and published by Frommer's. Close on its heels are Bellingham...For the expanded press release, log onto Frommers.com. Peter Sander is a professional author, researcher, and marketer. He...
- Idaho Falls, Idaho Gets Backward Compliment from USA Today.
- Newspaper article from: Post Register (Idaho Falls, ID) April 5, 2004 700+ words
...In evaluating emerging cities, authors Bert Sperling and Peter Sander took stock of 45 newly named Metropolitan Statistical Areas...Metropolitan Areas Evaluated in the U.S. and Canada; by Peter Sander and Bert Sperling (John Wiley & Sons; 832 pages...
- All clear for Chinas first independent engine-testing lab.
- Press release article from: M2 Presswire December 20, 2004 700+ words
...early December. This engine test stand is a milestone for the further development of the Chinese fuel sector, said Jan-Peter Sander, manager of the BASF global business unit Performance Chemicals for the Automotive and Oil Industry, at the signing of...