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Antigen engineering promotes induction of HIV-neutralizing antibodies.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Antigen engineering can promote the induction of HIV-neutralizing antibodies.
According to a study from the United States, "Understanding how neutralizing antibodies recognize HIV could aid the design of antigens that induce protective antibodies upon immunization. There have been several advances in this area of AIDS vaccine research, including structural elucidation of the core of two gp120 envelope glycoproteins and, more recently, determination of the structures of the broadly HIV-1-neutralizing antibodies b12, 2G12 and 2F5. The structures have enabled features governing the molecular interaction of each antibody with its epitope to be explored."
"For the antibody b12, this has resulted in the design of novel, tailored antigens aimed at inducing similar antibodies with equivalent neutralizing properties," said Ralph Pantophlet and Dennis R. Burton at the Scripps Research Institute. "This template-based approach to ...
- Antigen engineering promotes induction of HIV-neutralizing antibodies.
- Newspaper article from: AIDS Vaccine Week January 19, 2004 700+ words
...broadly HIV-1-neutralizing antibodies b12, 2G12 and...at the Scripps Research Institute. "This template...induction of HIV-neutralizing antibodies. Trends Mol...The Scripps Research Institute, 10550 North...
- Study: Neutralizing antibodies may sabotage efficacy of beta interferon.
- Newspaper article from: Pain & Central Nervous System Week November 4, 2002 700+ words
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- Virus-neutralizing antibodies essential for Friend retrovirus immunity.
- Newspaper article from: Medical Letter on the CDC & FDA October 31, 2004 700+ words
...amp; NewsRx.net) -- Virus-neutralizing antibodies play an essential role in sterilizing...cells is the production of virus-neutralizing antibodies rather than priming or reactivation...passive transfer of virus-neutralizing antibodies completely compensated for B cell...
- Neutralizing antibodies - and what they mean. (in multiple sclerosis care)
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- Press release article from: PR Newswire March 27, 2003 700+ words
...immunomodulating drugs developed neutralizing antibodies that would affect the drug's...while others are neutralizing. Neutralizing antibodies in the three interferon-beta...The article concluded that, "Neutralizing antibodies can appear early during the course...
- Polymer Coating Protects Adenovirus From Neutralizing Antibodies.
- Newspaper article from: Gene Therapy Weekly May 17, 2001 700+ words
...polymer, which protected it from neutralizing antibodies. K.D. Fisher and colleagues...susceptibility to preexisting neutralizing antibodies and the wide cell distribution...To protect adenovirus from neutralizing antibodies, Fisher and coworkers coated...
- Anti-CD80/Anti-CD86 Blocks Formation of Neutralizing Antibodies.
- Newspaper article from: Gene Therapy Weekly May 18, 2000 700+ words
...CD86 prevents the formation of neutralizing antibodies to adeno-associated virus...treatment prevents the formation of neutralizing antibodies to AAV." According to the researchers...treatment prevented formation of neutralizing antibodies in Balb/C mice that were injected...