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Severe acute respiratory syndrome -associated coronavirus vaccine shows promise in monkeys.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- A SARS-associated coronavirus vaccine shows promise for eliciting a strong specific immune response in monkeys.
According to recent research published in the journal Lancet, "The causative agent of severe acute respiratory syndrome (SARS) has been identified as a new type of coronavirus. Here, we have investigated the ability of adenoviral delivery of codon-optimized SARS-CoV strain Urbani structural antigens spike protein S1 fragment, membrane protein, and nucleocapsid protein to induce virus-specific broad immunity in rhesus macaques. We immunized rhesus macaques intramuscularly with a combination of the three Ads-SARS-CoV vectors or a control vector and gave a booster vaccination on day 28."
"The vaccinated animals all had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein," reported Wentao Gao and collaborators at the University of Pittsburgh and the Centers for Disease Control and Prevention in the United States. "All vaccinated animals showed strong neutralizing antibody responses to ...
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Source: HighBeam Research, Severe acute respiratory syndrome -associated coronavirus vaccine...