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Helix 1 peptide elicits antibodies against prion protein in mice.
2004 JAN 21 - (NewsRx.com & NewsRx.net) -- Helix 1 peptide immunization generates antibodies against the prion protein in wild-type mice.
"We present here the development of antibodies against prion protein in BALB/c mice using as antigen human helix I of PrP. This sequence is suggested to be involved in protein pathological conformational changes, and is distinguished from that of mice by one amino acid," researchers in Israel report.
"The immune tolerance to an 'almost-self' epitope and the poor immunogenicity of short peptides was overcome by using Multiple Antigen Peptide displaying eight copies of helix 1," said Michal Arbel and colleagues at Tel-Aviv University. "The generated antibodies recognize the whole prion protein with a high binding constant and the established protocol may lead to an active immunization towards therapeutics of prion disease."
Arbel and ...
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Source: HighBeam Research, Helix 1 peptide elicits antibodies against prion protein in mice.