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Modified adeno-associated virus type 2 circumvents human antibodies.
2004 JAN 7 - (NewsRx.com & NewsRx.net) -- Modified adeno-associated virus type 2 circumvents human antibodies.
"The high prevalence of human serum antibodies against adeno-associated virus type 2 (AAV) vectors represents a potential limitation for in vivo applications. Consequently, the development of AAV vectors able to escape antibody binding and neutralization is of importance. To identify capsid domains which contain major immunogenic epitopes, six AAV capsid mutants carrying peptide insertions in surface exposed loop regions (I-261, I-381, I-447, I-534, I-573, I-587) were analyzed," according to researchers in Germany.
"Two of these mutants, I-534 and I-573, showed an up to 70% reduced affinity for AAV antibodies as compared to wild-type AAV in the majority of serum samples. In addition, AAV mutant I-587 but not wild-type AAV efficiently transduced cells despite the presence of neutralizing antisera," wrote N.A. Huttner and colleagues, ...
- Adeno-associated virus-mediated kallikrein gene therapy prevents cardiac injury.
- Newspaper article from: Gene Therapy Weekly October 28, 2004 700+ words
...NewsRx.net) -- Adeno-associated virus-mediated kallikrein gene therapy prevents cardiac injury...published their study in Gene Therapy (Recombinant adeno-associated virus-mediated kallikrein gene therapy reduces hypertension and...
- Avigen Secures Exclusive Worldwide Rights to Hemophilia B Gene Therapy...
- Press release article from: PR Newswire July 8, 1999 700+ words
...specifically to Factor IX gene therapy using adeno-associated virus (AAV). The patent...the development of gene therapy products derived from adeno-associated virus for the treatment...Company's proposed gene therapy products are designed...
- AVIGEN DROPPING AAV GENE THERAPY, FAVORING TRADITION.(Avigen Inc)(adeno-...
- Magazine article from: BIOWORLD Today Pihl-Carey, Karen April 6, 2005 700+ words
...He participated in a gene therapy study using an adenoviral...the FDA stopped all gene therapy trials that use retroviral...which uses an adeno- associated virus (AAV) to deliver...decision not to fund AAV gene therapy has nothing to do with...
- Viral Vectors Used for in utero Gene Therapy in Mice.(adenovirus and...
- Magazine article from: Women's Health Weekly February 8, 2001 700+ words
...and adeno-associated virus (AAV) vectors...in utero gene therapy, researchers...and adeno-associated virus (AAV) vectors," Gene Therapy, 2000...and adeno-associated virus (AAV) vectors...in utero gene therapy efficacy...
- The use of recombinant adeno-associated virus in gene therapy is challenging.
- Newspaper article from: Gene Therapy Weekly May 29, 2003 700+ words
...recombinant adeno-associated virus in gene therapy is challenging...recombinant adeno-associated virus (AAV...for human gene therapy. One challenge...Recombinant adeno-associated virus: Formulation...strategies for a gene therapy vector...
- Hematopoietic Gene Therapy "Recombinant Adeno-Associated Virus-Based Vectors...
- Newspaper article from: Blood Weekly October 26, 1998 700+ words
...International Society for Experimental Hematology, held August 1-5, 1998, in Vancouver, British Columbia, Canada, "Gene therapy of hematopoietic stem cells could be instrumental in the treatment of numerous hematological disorders. The objective of...
- Recombinant Adeno-Associated Virus Vector Gene Therapy Discussed.
- Newspaper article from: Gene Therapy Weekly November 16, 2000 700+ words
...using the company's adeno-associated virus (AAV) vectors. Dr. Haim...recombinant AAV-TNFR:Fc vector gene therapy." The studies were undertaken...This article was prepared by Gene Therapy Weekly editors from staff...reports. Copyright 2000, Gene Therapy Weekly via ...
- Adeno-Associated Virus Gene Transfer Could Prevent Several...
- Newspaper article from: Immunotherapy Weekly January 16, 2002 700+ words
...recombinant adeno-associated virus (rAAV) vector-mediated gene therapy, according...cytokines. The gene therapy dampened...Adeno-associated virus vector...Recombinant adeno-associated virus (rAAV...cytokine gene therapy was host...
