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Subtype immunogenicity in Neisseria vaccine not dependent on form.
2004 JAN 7 - (NewsRx.com & NewsRx.net) -- The relative immunogenicity of PorA subtypes in a multivalent Neisseria meningitidis vaccine was not dependent on presentation form.
According to a study from the Netherlands, "The hexavalent meningococcal vaccine HexaMen, containing six PorAs on two vesicles, was tested in clinical studies. Although four-fold increases in serum bactericidal activity (SBA) titers against all of the PorAs were observed, there were significant differences between PorA-specific SBA titers. SBA titers were mainly directed against one PorA from each vesicle, P1.5-2,10 and P1.5-1,2-2, and were lower against the other PorAs, especially P1.7-2,4 and P1.19,15-1."
"We investigated whether these differences were due to immunological interference that resulted in competition between the three PorAs on the same vesicle or whether they were caused by a difference in the immunogenicities of the separate PorAs," said Thomas A. Luijkx and colleagues at the Netherlands Vaccine Institute. "Therefore, mice were immunized either with HexaMen, with six monovalent outer membrane vesicles (OMVs) representing the same six PorAs simultaneously (HexaMix), or with only one of the monovalent OMVs. The immunoglobulin G and SBA titers after HexaMen immunization in mice resembled the results obtained in clinical studies."
"Although immunization with HexaMix gave higher titers than immunization with HexaMen for some PorAs, the pattern of high and low titers was the same," reported Luijkx and his collaborators. "Similar differences in immunogenicity between subtypes were seen after ...
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Source: HighBeam Research, Subtype immunogenicity in Neisseria vaccine not dependent on form.