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Crossreactive antibodies against Plasmodium protein induced.
2004 JAN 7 - (NewsRx.com & NewsRx.net) -- Researchers have reported the induction of crossreactive antibodies to Plasmodium falciparum variant protein.
"The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), present on the surface of P. falciparum-parasitized erythrocytes (PE), plays a central role in naturally acquired immunity, although antibodies to PfEMP1 are predominantly variant specific. To overcome this major limitation for vaccine development, we immunized mice with three cysteine-rich interdomain 1 (CIDR1) domains of PfEMP1 that have the critical function of binding the PE to CD36 on endothelium and thus preventing spleen-dependent killing of the parasite," scientists writing in the journal Proceedings of the National Academy of Sciences USA report.
"The immunizations consisted of different combinations of three CIDR1 encoded by DNA followed by recombinant protein boost," said Sylvie Gratepanche at the National Institute of Allergy and Infectious Diseases and collaborators throughout the United States. "Immunizations with a single variant in a prime-boost regimen induced no or low crossreactivity toward heterologous CIDR1; ...
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Source: HighBeam Research, Crossreactive antibodies against Plasmodium protein induced.