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Human antibodies from immunized donors protect against anthrax.
2004 JAN 7 - (NewsRx.com & NewsRx.net) -- Human antibodies from immunized donors are protective against anthrax toxin in vivo.
"A panel of Fabs that neutralize anthrax toxin in vitro was selected from libraries generated from human donors vaccinated against anthrax. At least two of these antibodies protect rats from anthrax intoxication in vivo," investigators in the United States report.
"Fabs 83K7C and 63L1D bind with subnanomolar affinity to protective antigen (PA) 63, and Fab 63L1D neutralizes toxin substoichiometrically, inhibits lethal factor (LF) interaction with PA63 and binds to a conformational epitope formed by PA63," stated Martha A. Wild and collaborators at Alexion Antibody Technologies, Inc. and the Naval Medical Center in California.
Wild ...
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Source: HighBeam Research, Human antibodies from immunized donors protect against anthrax.