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MIC3 gene of Toxoplasma gondii is potent vaccine candidate.
2004 JAN 7 - (NewsRx.com & NewsRx.net) -- The MIC3 gene of Toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis.
"Infection with the intracellular protozoan parasite Toxoplasma gondii causes serious public health problems and is of great economic importance worldwide. The micronemal protein MIC3, which is a potent adhesin of T. gondii, could be a significant candidate vaccine against toxoplasmosis," researchers in France report.
"In this study, all CBA/J mice intramuscularly vaccinated with a plasmid encoding the immature form of the MIC3 protein (pMIC3i) produced specific anti-MIC3 immunoglobulin G (IgG) antibodies, and their sera displayed high antibody titers," said Alaa B. Ismael and colleagues at the University of Tours. "This response was increased by the co-administration of a plasmid encoding the granulocyte-macrophage colony-stimulating factor (pGM-CSF). Similarly, a specific and significant cellular immune response was obtained in mice immunized with pMIC3i, and this response was markedly enhanced by pGM-CSF co-administration."
"The cellular immune response was associated with the production of gamma interferon IFN-gamma, and interleukin-2 (IL-2), indicating that this was a Th1-type response," reported the investigators. "This was confirmed by the production of large amounts of IgG2a. Mice immunized with pMIC3i displayed significant protection against an oral challenge with T. ...
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Source: HighBeam Research, MIC3 gene of Toxoplasma gondii is potent vaccine candidate.