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Rodent intrapelvic muscles are suited for modeling human pelvic floor disorder.

Women's Health Weekly

| January 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Rodent intrapelvic muscles are suited for modeling human pelvic floor disorder.

According to a study from the United States, "in humans, the pelvic floor skeletal muscles support the viscera. Damage to innervation of these muscles during parturition may contribute to pelvic organ prolapse and urinary incontinence. Unfortunately, animal models that are suitable for studying parturition-induced pelvic floor neuropathy and its treatment are rare."

"The present study describes the intrapelvic skeletal muscles (i.e., the iliocaudalis, pubocaudalis, and coccygeus) and their innervation in the rat to assess its usefulness as a model for studies of pelvic floor nerve damage and repair. Dissection of rat intrapelvic skeletal muscles demonstrated a general similarity with human pelvic floor muscles," according to wrote R.E. Bremer and colleagues, Dynogen Pharmaceuticals Inc.

"Innervation of the iliocaudalis and pubocaudalis muscles (which together constitute the levator ani muscles) was provided by a nerve (the ''levator ani nerve'') that entered the pelvic cavity alongside the pelvic nerve, and then branched and penetrated the ventromedial (i.e., intrapelvic) surface of these muscles. Innervation of the rat coccygeus muscle (the ''coecygeal nerve'') was derived from two adjacent branches of the L6-S1 trunk that penetrated the muscle on its rostral edge."

"Acetylcholinesterase staining revealed a single motor ...

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