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Endometrial receptivity biomarkers may improve infertility diagnosis, treatment.

Women's Health Weekly

| January 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Understanding the function of biomarkers of endometrial receptivity will help diagnose and treat infertile couples more efficiently, researchers report.

According to recent research from Brazil, "Implantation is a phenomenon that involves an interaction between the embryo and maternal endometrium.

"There is, in the menstrual cycle, a short and precise period of time in which the maternal-embryonic interaction is optimal and culminates with adhesion and invasion of the blastocyst into the progesterone-induced secretory endometrium. This period is called nidation or implantation window," wrote M. Cavagna and colleagues, Santo Amaro University.

"In the implantation window, changes occur in endometrial epithelial morphology, characterized by the appearance of membrane projections called pinopodes. Pinopodes are progesterone-dependent organelles that took like apical cellular protrusions appearing between days 20 and 21 of the natural menstrual cycle," the researches wrote.

"There are many factors that regulate the changes typical of the implantation window and the appearance of the pinopodes. The ...

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