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GLUT1 protein expression is an indicator of hyperplasia grade cervical cancer.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- GLUT1 protein overexpression is an indicator of hyperplasia, transformation stages, and cervical cancer.
"We studied whether induction of glucose transporters (GLUTs) 1 to 4 correlates with human papillomavirus (HPV)-dependent malignant transformation of cervical epithelium. Tissue samples of cervical intraepithelial neoplasia (CIN grades 1-3), invasive carcinomas, and lymph node metastasis were examined," scientists in Germany report.
"HPV typing was performed. Tissue sections were immunostained with GLUT1 to GLUT4 antibodies. Messenger RNA (mRNA) in situ hybridization confirmed GLUT1 protein expression. Weak expression of GLUT1 was found in nondysplastic HPV-positive and HPV-negative epithelium; significant expression was observed in preneoplastic lesions, correlating with the degree of dysplasia.
"In CIN 3 high-risk HPV lesions, cervical cancer, and metastasis, GLUT1 was expressed at highest levels with a strong correlation of GLUT1 mRNA and protein expression. Immunostains for GLUT2 to GLUT4 were negative. Cervical tumor cells respond to enhanced glucose utilization by upregulation of GLUT1," wrote C. Rudlowski and coauthors.
The researchers ...
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