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Study: HPV test is more effective than Pap smear for cervical cancer screening.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- A new study concludes that in women 30 and older, the HPV (human papillomavirus) DNA test is more effective than the Pap smear alone in identifying women with cervical cancer or its precursors.
Investigators say the results of the study of 11,085 women should facilitate earlier treatment, while allowing others to avoid unnecessary, invasive follow-up procedures.
The study was published in the December 6, 2003, issue of The Lancet
The research used Digene Corp.'s (DIGE) DNAwithPap Test, which is the only Food and Drug Administration (FDA)-approved test that detects the presence of the human papillomavirus - the primary cause of cervical cancer. In contrast, the Pap smear relies on visual examination of cervical cells for abnormal changes. In the study, investigators found that HPV testing has a sensitivity of 97.1% for identifying women with cervical cancer or precursor conditions, compared to 76.6% for the Pap smear. This finding, the authors state in the study report, helps explain why invasive cancer often develops after an apparently normal smear.
"Use of HPV testing in primary testing in addition to cytology (the Pap smear) ... should prevent more cancers than the use of cytology alone," concluded Professor Jack Cuzick, PhD, lead investigator in the HART (HPV in Addition to Routine Testing) study and head of epidemiology for Cancer Research U.K. at Queen Mary's College in London, England. "The high rate of early detection in this study with HPV screening suggests the potential to save many more ...
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