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Study: Shows rhIGFBP-3 enhances sensitivity to Herceptin.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Insmed, Inc., (INSM) reported on data from recent studies of the company's proprietary anticancer compound, recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3).
These studies conducted in the laboratory of Dr. Brian Leyland-Jones of McGill University were designed to explore the ability of rhIGFBP-3 to sensitize breast cancer cells to Herceptin (Trastuzumab).
The results of this study, published in the abstract titled, "Recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3) as a potential therapeutic agent for the treatment of Herceptin-resistant breast cancer," demonstrated the following:
1) In Herceptin-resistant breast carcinoma cells there was an increased level of insulin-like growth factor receptor.
2) rhIGFBP-3 caused dose-dependent inhibition of Herceptin-resistant breast carcinoma growth.
3) rhIGFBP-3 in ...
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...3 in a mouse model of Herceptin-resistant breast cancer. The study demonstrated...rhIGFBP-3 inhibited Herceptin-resistant breast tumor growth by 67% compared to control, however, Herceptin only inhibited tumor growth...
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...previously progressed on trastuzumab (Herceptin*) containing regimens (including chemotherapy...after these patients had progressed on Herceptin, a single receptor (ErbB2) inhibitor...disease progressed following treatment with Herceptin was encouraging and suggests that simultaneous...
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- Press release article from: Business Wire October 15, 2008 700+ words
...boosts the effects of trastuzumab (Herceptin[TM]) against HER2-positive breast...prognosis than HER2-negative cancer. Herceptin is an important therapeutic option in...restore sensitivity to trastuzumab in resistant breast cancer cells, highlights a potential...
- Tamoxifen-Resistant Breast Cancers Alter Their Traits, Become Receptive to New...
- News wire article from: Ascribe Higher Education News Service December 13, 2002 700+ words
...responsive to other types of drugs, including Herceptin, according to oncologists at the Duke...their qualities and become receptive to Herceptin and other drugs that target the HER...resistant tumors." Tamoxifen and Herceptin are two front-line drugs that shrink...
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- Magazine article from: BIOWORLD Today September 2, 1998 700+ words
...track drug in May, Genentech Inc.'s Herceptin, a monoclonal antibody designed to combat...Committee today. In assessing the merits of Herceptin, the committee will be reviewing the...fruition the promise of biotechnology." Herceptin is a humanized monoclonal antibody against...
- Herceptin.(More about ... Breast cancer)(Report)
- Magazine article from: CME: Your SA Journal of CPD Boeddinghaus, Irene Gudgeon, Anne October 1, 2008 700+ words
The incorporation of the name Herceptin into everyday medical (and lay...littered with fortuitous finds, Herceptin is not one of them. This drug was...on surrounding tissue. What is Herceptin? * Herceptin is trastuzumab, a...
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- Press release article from: PR Newswire Europe May 16, 2005 700+ words
...targeted anti-cancer therapy Herceptin (trastuzumab) achieved a highly...positive breast cancer. HERA (HERceptin Adjuvant), an international...study, investigated treatment with Herceptin for 12 or 24 months versus no treatment...
