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Genes upregulated by hypoxia are strategic targets for cancer therapy.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Genes upregulated by hypoxia are strategic targets for cancer therapy.
According to recent research published in the journal Biomedicine & Pharmacotherapy, "hypoxia is a stress that causes alterations in signal transduction and gene instability. In the cancer microenvironment, hypoxia plays a significant role in forming a tumor phenotype and tumor progression. We aimed to identify the genes upregulated by hypoxia in human breast cancer cell lines, a hormone-dependent MCF-7 and a hormone-independent MDA-MB-231, using microarray analysis."
"These cells were exposed to two oxygen concentrations such as 21% and 1% in a time-course. Out of 12,625 genes, 26 genes were identified as commonly upregulated in both MCF-7 and MDA-MB-231 cells. Some of these genes were already reported as hypoxia-related, but some of those were identified newly," reported H. Bando and colleagues, Tokyo Metropolitan Cancer & Infectious Diseases Center, Breast Cancer Research Group.
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Source: HighBeam Research, Genes upregulated by hypoxia are strategic targets for cancer therapy.