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Expression of transglutaminases displayed in human breast cancer.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Breast cancer displays an aberrant expression of transglutaminases (TGase), wherein the levels of TGases-2, 3, and 7 are related to node involvement and patient outcome, researchers say.
According to a study from Wales, "Implicated in several physiologic processes, including tumor-host, some TGases have been noted to play a regulatory role in the extracellular matrix in cell adhesion and migration of cancer cells.
"This study sought to determine the level of expression of TGases and their possible clinical significance in a cohort of human breast cancer patients using RT-PCR and quantitative RT-PCR. Normal breast tissues generally expressed low levels of TGases-1, 2, 3, and 7, and higher levels of TGases-4, 5, and plasma TGase (FXIII)," wrote W.G. Jiang and colleagues, University of Wales College of Cardiff, College of Medicine.
"Significantly increased levels of transcripts of TGases-4 and 7, and significantly lower levels of FXIII were seen in tumor tissues (n=110) compared with normal mammary tissues (n=27), p=.05, 0.04, and 0.05, respectively," the researchers wrote.
"Node-positive tumors exhibited significantly higher levels of TGase-2 and lower levels of TGase-3 (p=.05 and .046, ...
- Expression of transglutaminases displayed in human breast cancer.
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