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Drug-induced apoptosis mechanism via DR-dependent pathway not fully understood.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Apoptosis in drug-resistant cells is induced via DR-independent pathways mediated by mitochondrial dysfunction, researchers report.
According to recent research from Japan, "Apoptosis is a crucial event for anticancer drug efficacy.
"The signal pathways activated by anticancer drugs are classified as death receptor (DR)-dependent or -independent. The mechanisms by which anticancer drugs induce apoptosis via DR-dependent pathways are not fully understood," wrote R. Kim and colleagues, Hiroshima University, Research Institute Radiation Biology & Medicine.
"In the present study, we assessed differential activation of signal transduction pathways leading to apoptosis by anticancer drugs in breast cancer cell lines. Three breast cancer cell lines, MDA-MB-231, MCF-7, and MCF-7(ADM), which are drug-resistant, were used. Drug sensitivity and apoptosis were assessed by MTT assay and TUNEL, respectively," the researchers wrote.
"Expression of apoptosis-related protein was assessed by Western blotting and RTPCR. The sensitivities of MDA-MB-231 and MCF-7 cells to mitomycin C (MMC) and adriamycin (ADM) were similar. In contrast, sensitivity of MDA-MB-231 cells to paclitaxel (TXL) was 30-fold greater than that of MCF-7 cells, 0.03 micro M in MDA-MB-231 and 0.9 micro M in MCF-7 cells, respectively," the researchers wrote.
"Treatment with MMC increased expression of DR4 and Fas in a time-dependent manner ...
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Source: HighBeam Research, Drug-induced apoptosis mechanism via DR-dependent pathway not fully...