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Combination genomics technique greatly improves breast carcinoma detection.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Combining cytogenetic and DNA flow cytometric analyses of breast carcinomas significantly improves the information obtained by either technique used alone, researchers say.
"The cytogenetic and DNA flow cytometric findings in 242 breast carcinomas were compared. The combined use of both techniques improved the detection of abnormal cell populations from 65% by cytogenetic analysis alone and 59% by DNA flow cytometric analysis alone to 84%. Informative and comparable cytogenetic and flow cytometric data were obtained for 155 tumors," scientists writing in the journal Cancer Genetics and Cytogenetics report.
"Among these 155 tumors, there was good concordance (64%) between the estimates of genomic changes by the two methods. Most discrepancies were among the DNA-diploid cases, where cytogenetic analysis detected small genomic changes. There were, however, also some exceptions in which large genomic changes detected by one method were missed by the other," wrote A. Adeyinka and colleagues, University of Lund Hospital, Department of Clinical Genetics.
"Of the specific breast cancer-associated cytogenetic aberrations subjected to separate correlation analysis, polysomy for chromosome 20 was significantly associated ...
- A Flow Cytometric Opsonophagocytic Assay for Measurement of Functional...
- Newspaper article from: Vaccine Weekly August 30, 1999 700+ words
...Goldblatt, D.; Carlone, G.M. "A Flow Cytometric Opsonophagocytic Assay for Measurement...protection. We developed a semiautomated flow cytometric opsonophagocytosis assay using HL...and 23F) as bacterial targets. The flow cytometric opsonophagocytosis assay was highly...
- Novel Flow Cytometric Technique Helps Assess Possibility of Lowering Platelet...
- Newspaper article from: Blood Weekly December 21, 2000 700+ words
...They tested their standardized flow cytometric method in patients with malignant...Applying a mathematical model, this flow cytometric method was shown to have a detection...researchers reported ("Standardized flow cytometric method for the accurate determination...
- Flow cytometric assay detects apoptosis proteins in residual tumor cells.
- Newspaper article from: Cancer Weekly June 10, 2003 700+ words
...com & NewsRx.net) -- A flow cytometric assay can measure apoptosis protein...scientists in the Netherlands explained. "Flow cytometric MRD detection by the establishment...follow-up: p = 0.43)." "The flow cytometric protocol thus enables analysis of...
- Novel monoclonal antibodies facilitate flow cytometric Toxoplasma detection.
- Newspaper article from: Obesity, Fitness & Wellness Week June 19, 2004 700+ words
...Novel monoclonal antibodies facilitate flow cytometric diagnosis of toxoplasmosis. In a...gondii RH tachyzoites were used for flow cytometric detection of intracellular parasites...proteins are highly useful for the flow cytometric detection of intracellular T. gondii...
- Flow cytometric assay for responses to anthrax vaccine developed.
- Newspaper article from: Medical Letter on the CDC & FDA January 25, 2004 700+ words
...Scientists have developed a flow cytometric assay using TNF-alpha detection...This study describes a four-color flow cytometric assay that detects CD4+ T cell responses...Methods (TNF-alpha detection using a flow cytometric assay to determine cellular responses...
- Two-Color, Cytokeratin-Labeled DNA Flow Cytometric Analysis of 332 Breast...
- Magazine article from: Archives of Pathology & Laboratory Medicine Prasad, Anil R. Divine, George Zarbo, Richard J. March 1, 2001 700+ words
...In the last decade, the study of flow cytometric data--especially with regard to...control leave the routine use of DNA flow cytometric analysis for treatment decisions in...demonstrate prognostic value. Contradictory flow cytometric findings may result from differences...
- CLSI Establishes Performance Guidelines for Clinical Flow Cytometric Analysis...
- Press release article from: Business Wire May 30, 2007 700+ words
...formerly NCCLS) document, Clinical Flow Cytometric Analysis of Neoplastic Hematolymphoid...neoplasia; * clinical utility of flow cytometric analysis in new disease categories...immunophenotypic markers; and * the role of flow cytometric immunophenotyping in evaluation of...
- Flow cytometric method used to assess lipid accumulation in fat cells.
- Newspaper article from: Obesity, Fitness & Wellness Week August 7, 2004 700+ words
...amp; NewsRx.net) -- Researchers have used a simple flow cytometric method to assess lipid accumulation in fat cells. "Adipogenesis...published their study in the Journal of Lipid Research (Simple flow cytometric method used to assess lipid accumulation in fat cells...