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Breast cancer risk from antibiotics may be due to altered immunity, microflora.

Women's Health Weekly

| January 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Breast cancer may develop with sustained antibiotic use due to influence on immunity as well as reduced intestinal microflora carcinogen processing.

According to recent research published in the journal Cancer Causes & Control, "the hypothesis that antibiotic use may increase cancer risk was first proposed several decades ago, and some research suggests an increased risk of breast cancer among women with conditions likely to require longterm antibiotic use (e.g., acne, recurrent urinary-tract infections).

"However, this hypothesis has not been verified and the possible biological mechanisms are not entirely clear. A recent cohort study in Finland reported an increased risk of breast cancer is associated with antibiotic use for UTI.

"The effect of antibiotics on the ability of intestinal microflora to metabolize phytochemicals from edible plants into compounds that may protect against cancer was proposed as a potential mechanism.

"We extend this hypothesis by proposing that antibiotic use may be associated with risk of breast cancer through effects on immune and inflammatory factors such as: cytokines, T lymphocytes, prostaglandins, matrix metalloproteinases, as well as ...

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