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Aromatase inhibitors' signal disruption mechanism differs from Tamoxifen.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Aromatase inhibitors for breast cancer alter estrogen-receptor signaling differently than tamoxifen, researchers say.
According to a study from England, "Endocrine therapy with tamoxifen has been the mainstay of treatment for hormone-sensitive breast cancer for more than 20 years.
"An alternative strategy of estrogen deprivation in postmenopausal women with aromatase inhibitors is set to replace tamoxifen based on better efficacy and a delay in the emergence of endocrine resistance," wrote S.R.D. Johnston and colleagues, Royal Marsden Hospital, Breast Unit.
The researchers concluded: "There are fundamental differences in how tamoxifen and aromatase inhibitors alter estrogen-receptor signaling. Understanding the response ...
- Concerns crop up about aromatase inhibitors. (Adjuvant Therapy for Breast...
- Magazine article from: Family Practice News Jancin, Bruce February 15, 2003 700+ words
...to develop the aromatase inhibitors as breast cancer chemoprevention...clinical trials of aromatase inhibitors for breast cancer chemoprevention...investigation of the aromatase inhibitors in breast cancer prevention despite...
- Aromatase inhibitors improve breast cancer survival.(cancer treatments)(Brief...
- Magazine article from: Focus on Healthy Aging December 1, 2006 700+ words
Score another win for the class of breast cancer drugs known as the aromatase inhibitors. A study in the September 20 Journal of...significantly improve survival in women with advanced breast cancer compared with the standard drug, tamoxifen...
- Research and Markets: Aromatase Inhibitors in Breast Cancer:.
- Press release article from: Business Wire May 6, 2004 700+ words
...announced the addition of Aromatase Inhibitors in Breast Cancer to their offering...the world market for aromatase inhibitors was valued at $420...the market soon. Aromatase Inhibitors in Breast Cancer is a timely strategic...
- Aromatase inhibitors and inactivators in breast cancer: these potent inhibitors...
- Magazine article from: British Medical Journal Lonning, Per Eystein October 20, 2001 700+ words
...suggest that aromatase inhibitors could be a feasible...receptor positive breast cancer. (1) Several...for subsequent breast cancer suggesting that aromatase inhibitors and inactivators...in preventing breast cancer. (14) If ongoing...
- Aromatase Inhibitors Declared Superior to Tamoxifen in the Adjuvant Treatment...
- Press release article from: PR Newswire August 1, 2006 700+ words
...panel of breast cancer specialists...value of aromatase inhibitors such as ARIMIDEX...of leading breast cancer specialists...agreed that aromatase inhibitors (AIs) surpass...the use of aromatase inhibitors in early breast cancer, and while...
- Aromatase inhibitors show promise against postmenopausal breast cancer.
- Newspaper article from: Biotech Week May 26, 2004 700+ words
...net) -- Aromatase inhibitors show promise...postmenopausal breast cancer. "This article...comprehensive review of aromatase inhibitors (AIs) for...searches were aromatase inhibitors, estrogen, and breast cancer. Limits included...
- Aromatase inhibitors for postmenopausal breast cancer therapy reviewed.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...Researchers review aromatase inhibitors for the treatment...postmenopausal breast cancer in a recent...searches were aromatase inhibitors, estrogen, and breast cancer. Limits...Society (Aromatase inhibitors: Current...postmenopausal breast ...
- University of Maryland Scientist Receives 2005 Charles F. Kettering Prize for...
- News wire article from: Europe Intelligence Wire June 16, 2005 700+ words
...developing aromatase inhibitors, a new class...to treat breast cancer. The Kettering...drugs called aromatase inhibitors now in use...recurrence of breast cancer in postmenopausal...approved three aromatase inhibitors for the treatment of breast ...
- Aromatase inhibitors constitute new endocrine therapy for breast cancer.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...net) -- Aromatase inhibitors constitute...therapy for breast cancer. "Estrogens...dependent breast cancer," researchers...Competitive aromatase inhibitors are molecules...Medicine (Aromatase inhibitors: New endocrine...treatment of breast ...
- Exemestane and aromatase inhibitors play role in breast cancer management.
- Newspaper article from: Vaccine Weekly April 21, 2004 700+ words
...Exemestane and aromatase inhibitors play a role...advanced breast cancer. "In metastatic...advanced breast cancer, aromatase inhibitors and inactivators...Exemestane and aromatase inhibitors in the management...advanced breast cancer. ...
Source: HighBeam Research, Aromatase inhibitors' signal disruption mechanism differs from...