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A decreased level of ERbeta mRNA may be associated with breast tumorigenesis.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- A decreased level of ERbeta mRNA may be associated with breast tumorigenesis and DNA methylation is an important mechanism for ERbeta gene silencing in breast cancer, researchers say.
"Two novel estrogen receptor beta (ERbeta) mRNA isoforms that diverge in their 5'-untranslated regions, ERbeta mRNA (0K-1) and ERbeta mRNA (0N-1), have recently been identified," researchers in Sweden report.
"This indicates that transcription of the human ERbeta gene occurs from at least two different promoters, named promoter 0K and promoter 0N. The aim of this study was to investigate the expression of ERbeta isoforms in primary cultures of normal breast epithelial cells, a panel of breast cancer cell lines and in normal breast and breast cancer tissues; and to examine whether methylation of the two ERbeta promoters is involved in regulation of ERbeta gene expression," wrote C.Y. Zhao and colleagues, Karolinska Institute.
"Using quantitative real-time PCR techniques, we found that ERbeta mRNA levels were significantly lower in breast cancer cell lines than in primary cultures of normal breast epithelial cells. Bisulfite genomic sequencing analysis revealed that two promoters of the ERbeta gene exhibit distinct methylation patterns," the researchers wrote.
"Promoter 0N was unmethylated in normal breast epithelial cells, but extensively methylated in breast cancer cell lines. In contrast, promoter 0K was unmethylated in both ...
- A decreased level of ERbeta mRNA may be associated with breast tumorigenesis.
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