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Hypoxic myocytes produce growth factor that stimulates COX-2 production.
2004 JAN 1 - (NewsRx.com & NewsRx.net) -- Hypoxic myocytes produce growth factor that stimulates COX-2 production.
According to published research from the United States, "there is increasing evidence that cyclooxygenase (COX)-2 possess both angiogenic and cardioprotective properties. We examined the effects of hypoxic cardiac myocytes (H9c2 cells) on COX-2 expression in human umbilical vein endothelial cells (HUVECs) to determine the pathway involved in COX-2 regulation. The medium from hypoxic (
"HMCM induced a transient increase of COX-2 mRNA expression at 1 and 3 hours without affecting the COX-1 mRNA level. A similar effect also observed in HMCM from cultured primary cardiac myocytes (rat neonatal cardiac myocytes). The increased COX-2 mRNA was associated with a time-dependent increase in COX-2 protein expression," reported G.F. Wu and colleagues, Harvard University, School of Medicine.
"COX-2 was significantly induced by VEGF (4.86[+ or -]1.03-fold) and IL-1beta; (3.93[+ or -]0.89-fold) and slightly increased by TNF-alpha; but not by FGF2, IGF-1, or PDGFs. Analysis of proteins secreted in HMCM showed increased levels of VEGF but not IL-1beta; or TNF-alpha;. The HMCM-induced COX-2 expression was inhibited by the addition of an anti-VEGF neutralizing antibody. VEGF induced endothelial cell COX-2 expression by both increasing COX-2 transcription and prolonging the COX-2 mRNA half-life," scientists said.
"Furthermore, staurosporine, a nonselective PKC inhibitor, prevented the induction of VEGF by hypoxia. Both a selective PKC-alpha; and -beta; inhibitor and an inducible nitric oxide ...
- Hypoxia/reoxygenation induces cyclophilin A release from rat cardiac myocytes.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...induces CyPA release from cultured rat cardiac myocytes. Scientists in Japan "previously...analyzed the conditioned media from cardiac myocytes subjected to hypoxia/reoxygenation...one of the proteins secreted from cardiac myocytes in response to hypoxia/reoxygenation...
- Length dependence of contractile properties altered in cardiac myocytes.
- Newspaper article from: Obesity, Fitness & Wellness Week April 19, 2003 700+ words
...dependence of contractile properties in cardiac myocytes. According to recent research from...training increases the sensitivity of rat cardiac myocytes to activation by Ca2+, and this...increases this length dependence in cardiac myocytes. "Female Sprague-Dawley rats were...
- Neonatal Rat Cardiac Myocytes.(Product News)
- Magazine article from: Bioscience Technology November 1, 2007 700+ words
Clonetics Neonatal Rat Cardiac Myocytes are available for use in cardiovascular...cryopreserved cells offer functional, beating cardiac myocytes upon thaw, at the user's convenience. Cardiac myocytes provide research laboratories with ready...
- BAG-1 proteins protect cardiac myocytes from simulated apoptosis.
- Newspaper article from: Heart Disease Weekly July 18, 2004 700+ words
...expression and function of BAG-1 proteins in primary cardiac myocytes (CMs) and the Langendorff-perfused intact heart. The...Journal of Biological Chemistry (BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis...
- S100B gene regulated by alpha[subscript]1-adrenergic stimulation in cardiac...
- Newspaper article from: Heart Disease Weekly March 2, 2003 700+ words
...of this pathway. "We transfected cultured neonatal rat cardiac myocytes with a luciferase reporter gene driven by the maximal human...the S100B gene by alpha(1)-adrenergic stimulation in cardiac myocytes. Am J Physiol, 2003;284(1):H193-H203). The...
- Tissue factor expressed by cardiac myocytes protects the heart from hemorrhage.
- Newspaper article from: Heart Disease Weekly February 16, 2003 700+ words
...mice appears to be caused by hemorrhage from cardiac vessels due to impaired hemostasis. We propose that TF expression by cardiac myocytes provides a secondary hemostatic barrier to protect the heart from hemorrhage." Pawlinski and colleagues published their...
- Bacterial nucleic acids induce contraction depression in rat cardiac myocytes.
- Newspaper article from: Biotech Week May 26, 2004 700+ words
...26 - (NewsRx.com & NewsRx.net) -- Bacterial nucleic acids induce contraction depression in cultured murine cardiac myocytes. "Sepsis and septic shock, the systemic immunologic and pathophysiologic response to overwhelming infection, are associated...
- REGULATION OF P38 MAP KINASE ACTIVITY IN NEONATAL RAT CARDIAC MYOCYTES BY...
- Magazine article from: Heart Sood, A McPhee, I Cobbe, S M Houslay, M D May 1, 2001 700+ words
...Biochemistry I McPhee [2] S M Cobbe [1] M D Houslay [2] Cardiac myocytes exhibit the adaptive phenomenon of preconditioning whereby...modulation of p38MAPK activity by cyclic AMP signalling in cardiac myocytes and that this process can be controlled by type 4 PDEs...
- Phospholemman modulates Na+/Ca2+ exchange in adult rat cardiac myocytes.
- Newspaper article from: Heart Disease Weekly February 23, 2003 700+ words
...partly by inhibiting Na+/Ca2+ exchange," they wrote (Phospholemman modulates Na+/Ca2+ exchange in adult rat cardiac myocytes. Amer J Physiol-heart Circ Phy, 2003;284(1):H225-H233). For additional information, contact J.Y. Cheung...
- Goal is to research about pathways of B lymphocytes and cardiac myocytes.
- Newspaper article from: Immunotherapy Weekly February 5, 2003 700+ words
...signaling networks. "Pathways will be studied intensively in two cells - B lymphocytes (the cells of the immune system) and cardiac myocytes - to facilitate quantitative modeling," stated A.G. Gilman and colleagues, University of Texas, Southwest Medical...
Source: HighBeam Research, Hypoxic myocytes produce growth factor that stimulates COX-2...