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2004 JAN 1 - (NewsRx.com & NewsRx.net) -- TRAF6 has many essential functions spanning immune, bone, endocrine, and nerve functions.
"Tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) is a crucial signaling molecule regulating a diverse array of physiological processes, including adaptive immunity, innate immunity, bone metabolism, and the development of several tissues including lymph nodes, mammary glands, skin, and the CNS," scientists writing in the journal Bioessays report.
"It is a member of a group of 6 closely related TRAF proteins, which serve as adapter molecules, coupling the TNF receptor (TNFR) superfamily to intracellular signaling events. Among the TRAF proteins, TRAF6 is unique in that, in addition to mediating TNFR family signaling, it is also essential for signaling downstream of an unrelated family of receptors, the interleukin-1 (IL-1) receptor/Toll-like receptor (IL-1R/TLR) superfamily.
"Gene targeting experiments have identified several indispensable physiological functions of TRAF6, and structural and biochemical studies have revealed the ...