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Expression of protein of Plasmodium yoelii protects against malaria.
2003 DEC 17 - (NewsRx.com & NewsRx.net) -- Priming-boosting immunization with recombinant cold-adapted influenza and modified vaccinia Ankara viruses expressing a CD8[superscript]+-T-cell epitope from the circumsporozoite protein of Plasmodium yoelii was protective against malaria.
"We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8[superscript]+-T-cell epitope derived from malaria sporozoites," researchers in the United States and Spain report.
"This vaccination regimen elicited high levels of protection against malaria," said Gloria Gonzalez-Aseguinolaza and collaborators at New York University in the U.S. and the Centro Nacional de Biotecnologia in Spain. "This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated."
Gonzalez-Aseguinolaza and her coauthors published their study in the ...
- Plasmodium yoelii merozoite antigen protects mice against parasitemia.
- Newspaper article from: Vaccine Weekly January 8, 2003 700+ words
...a vaccine against a challenge of Plasmodium yoelii sporozoites in C57BL/6 mice (Merozoite...against exoerythrocytic forms of Plasmodium yoelii, Infect Immun, 2002;70(11...merozoite surface protein 1 (MSP1) of Plasmodium yoelii fused to heat-shock cognate protein...
- Plasmodium yoelii mdr1 gene from artemisinin-resistant line characterized.
- Newspaper article from: Anti-Infectives Week May 10, 2004 700+ words
...artemisinin-resistant strain of the murine malarial pathogen Plasmodium yoelii has been characterized. "The molecular mechanisms by...published their study in the Journal of Parasitology (Plasmodium yoelii: Identification and partial characterization of an mdr1...
- MSP combination boosts protection against Plasmodium yoelii in rat model.(Brief...
- Newspaper article from: Vaccine Weekly January 22, 2003 700+ words
...researchers tested the hypothesis in rats challenged with Plasmodium yoelii "by comparing the degree of protection conferred by immunization...and 1 enhances protection against lethal challenge with Plasmodium yoelii. Infect Immun, 2002;70(12):6606-6613). The...
- Research from New York University, Medical Department broadens understanding of...
- Newspaper article from: Malaria Weekly (Atlanta, GA) February 23, 2009 700+ words
...Mice infected with Plasmodium yoelii and isolated P. yoelii...Orengo and colleagues, New York University, Medical...Malaria Journal (A Plasmodium yoelii soluble factor inhibits...contact A. Rodriguez, New York University, School...
- Murine plasmodial ABC genes identified.
- Newspaper article from: Biotech Week March 10, 2004 700+ words
...Plasmodia." "We queried the Plasmodium yoelii genome with the ABC signature...expression analysis of ABC genes in Plasmodium yoelii and P. berghei. Parasitol...Verlag, 175 Fifth Avenue, New York, NY 10010, USA. The information...
- Studies from G. Chen et al in the area of malaria described.
- Newspaper article from: Malaria Weekly (Atlanta, GA) November 2, 2009 700+ words
...of China, "The outcome of Plasmodium yoelii 17XL-infected BALB/c and...regulatory T cells on early Plasmodium yoelii 17XL infection in BALB/c mice...32 Avenue of the Americas, New York, NY 10013-2473, USA. Keywords...
- Hepatocyte CD81 expression needed for plasmodial sporozoite infectivity.
- Newspaper article from: Proteomics Weekly March 3, 2003 700+ words
...Plasmodium falciparum and rodent Plasmodium yoelii sporozoite infectivity...for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat...345 Park Avenue South, New York, NY 10010-1707, USA. The...
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- Magazine article from: BIOWORLD Today November 17, 2003 700+ words
...Molecular Parasitology at New York University to provide...mouse malaria parasite Plasmodium yoelii. Gilead Sciences Inc...amp; Lerach LLP, of New York. The suit alleges that...Stock Market Inc., of New York, performed its semi...
Source: HighBeam Research, Expression of protein of Plasmodium yoelii protects against malaria.