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Antibodies to histone-like protein protect against Histoplasma.
2003 DEC 17 - (NewsRx.com & NewsRx.net) -- Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
"A protective role for antibodies has not previously been described for host defense against the pathogenic fungus Histoplasma capsulatum (Hc). Mouse monoclonal antibodies (mAbs) were generated from mice immunized with Hc yeast that binds the cell surface of Hc. Administration of mAbs before Hc infection reduced fungal burden, decreased pulmonary inflammation, and prolonged survival in a murine infection model," investigators in the United States report.
"Protection mediated by mAbs was associated with enhanced levels of IL-4, IL-6, and IFN-gamma in the lungs of infected mice," said Joshua D. Nosanchuk and collaborators at Albert Einstein College of Medicine and the University of Cincinnati. "The mAbs increased phagocytosis of yeast by J774.16 cells through a CR3-dependent process. Ingestion of mAb-opsonized Hc by J774.16 macrophage-like cells was associated with yeast cell growth inhibition and killing."
"The mAbs bound to a 17-kDa antigen expressed on the surface of Hc," reported Nosanchuk and his colleagues. "The antigen was identified as a ...
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...Relations Manager of Albert Einstein College of Medicine...Medical Center for Albert Einstein College of Medicineand...montekids.org. Albert Einstein College of Medicine...medical education and clinical investigation. It is home to...
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- Press release article from: PR Newswire March 27, 2007 700+ words
Albert Einstein Healthcare Network advances health...solutions, today announced that Albert Einstein Healthcare Network is in the process...Suite. Through these solutions, Albert Einstein Healthcare Network expects improvements...
- Artificial Life Brings Albert Einstein ALife.
- Press release article from: PR Newswire May 25, 1999 700+ words
...Artificial Life, Inc. Creates a Virtual Albert Einstein on CD-ROM BOSTON, May 25 /PRNewswire...program explaining the life and work of Albert Einstein. The application will be the company...s PersonalTutor(TM). Called Albert Einstein ALife, the CD-ROM learning program...
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- Press release article from: Business Wire May 31, 2005 700+ words
...NovaVision, Inc. today announced that Albert Einstein Medical Center has entered into an agreement...Jefferson University School of Medicine. Albert Einstein Medical Center is part of Albert Einstein Healthcare Network, a private, not...
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- Press release article from: Business Wire August 26, 2003 700+ words
...BUSINESS WIRE)--Aug. 26, 2003 Albert Einstein Healthcare Network and Tenet Healthcare...entered into a contract under which Albert Einstein Healthcare Network will acquire the...is currently headquartered next to Albert Einstein Medical Center. Elkins Park Hospital...
- ALBERT EINSTEIN HOSPITAL OFFERS IMAGE-GUIDED RADIATION THERAPY.
- Newspaper article from: Imaging Update February 1, 2007 700+ words
Albert Einstein Jewish Hospital, Sao Paulo, Brazil...variety of indications. Physicians at Albert Einstein now have access to this advanced...high quality cancer treatment, Albert Einstein Jewish Hospital has selected the...
- Albert Einstein Jewish Hospital Becomes First Facility in South America to...
- Press release article from: PR Newswire December 20, 2006 700+ words
...Brazil, Dec. 20 /PRNewswire/ -- Albert Einstein Jewish Hospital, one of the leaders...variety of indications. Physicians at Albert Einstein now have access to this advanced tumor...provide high quality cancer treatment, Albert Einstein Jewish Hospital has selected the BrainLAB...