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T-cell response against hepatitis C virus optimized.
2003 DEC 17 - (NewsRx.com & NewsRx.net) -- T-cell responses against hepatitis C virus E2 optimized by antigen engineering in DNA immunization.
"Although DNA immunization is a safe and efficient method for inducing cellular immune responses, it generates relatively weak and slow immune responses. Here, we investigated the effect of hepatitis C virus (HCV) antigen modifications on the induction of T-cell responses in DNA immunization. It is likely that the strength of T-cell responses has an inverse relationship with the length of the insert DNA," researchers in South Korea report.
"Interestingly, a mixture of several plasmids carrying each gene induced a higher level of T-cell responses than a single plasmid expressing a long polyprotein," said Jin-Won Youn and colleagues at Pohang University of Science and Technology. "Moreover, the presence of a transmembrane domain in HCV E2 resulted in stronger T-cell responses against E2 protein than its absence. Taken together, our results indicate that the tailored modifications of DNA-encoded antigens are capable of optimizing the ...
- Protective T-Cell Responses Induced by DNA Immunization.(Brief Article)
- Newspaper article from: Vaccine Weekly November 1, 2000 700+ words
...new study shows. "CD8(+) T-cell responses can be induced by DNA immunization, but little is known about the kinetics...phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization," Journal of Virology, 2000;74...
- Protective T-Cell Responses Induced by DNA Immunization.
- Newspaper article from: Gene Therapy Weekly November 2, 2000 700+ words
...new study shows. "CD8(+) T-cell responses can be induced by DNA immunization, but little is known about the kinetics...phenotypic analyses of CD8(+) T-cell responses induced by DNA immunization," Journal of Virology, 2000;74...
- DNA Immunization with Ras Oncogene Peptide Elicits T-Cell Responses.
- Newspaper article from: Immunotherapy Weekly February 14, 2001 700+ words
...and CD8(+) T-cell epitopes in a nested configuration and elicits both T-cell subset responses by peptide or DNA immunization," Cell Immunol, 2000;205(2):73-83). "This peptide reflected ras sequence 4-16, and contained the substitution...
- DNA Immunization with Ras Oncogene Peptide Elicits T-Cell Responses.(Brief...
- Newspaper article from: Vaccine Weekly February 14, 2001 700+ words
...and CD8(+) T-cell epitopes in a nested configuration and elicits both T-cell subset responses by peptide or DNA immunization," Cell Immunol, 2000;205(2):73-83). "This peptide reflected ras sequence 4-16, and contained the substitution...
- DNA Immunization Induces Protective Immunity Against Plasmodium falciparum.
- Newspaper article from: Blood Weekly February 15, 2001 700+ words
...Infection and Immunity ("DNA immunization by Plasmodium falciparum liver...by high gamma interferon T-cell responses and a predominance of immunoglobulin...pre-erythrocytic antigen * DNA immunization of mice with PfLSA3 induced...
- DNA immunization enhances immune response to fowlpox-based SIVmac vaccine.
- Newspaper article from: Vaccine Weekly October 8, 2003 700+ words
...NewsRx.net) -- Prior DNA immunization enhances immune response to...broadened Gag-specific T-cell responses measured by tetramer staining...their study in Virology (Prior DNA immunization enhances immune response to...
- DNA Immunization Induces Protective Immunity Against Plasmodium...
- Newspaper article from: Vaccine Weekly February 14, 2001 700+ words
...Infection and Immunity ("DNA immunization by Plasmodium falciparum liver...by high gamma interferon T-cell responses and a predominance of immunoglobulin...pre-erythrocytic antigen * DNA immunization of mice with PfLSA3 induced...
- DNA immunization technology patents licensed. (Dynavax Technologies Corp.'s...
- Newspaper article from: Vaccine Weekly January 19, 1998 700+ words
...other firm's patented technology for DNA immunization with its own in developing products...to certain Vical patents covering DNA immunization for Dynavax's use in the fields...to certain Dynavax patents covering DNA immunization through the skin for use in the fields...