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BAFF overexpression in lupus may be blockable with decoy receptor, monoclonal.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- In lupus erythematosus, excess BAFF expression may be curbed by treatment with decoy BAFF receptor or with monoclonal antibodies; may stop symptoms.
"BAFF, a member of the family of tumor necrosis factor (TNF) ligands, is essential for the development of peripheral mature, long lived B lymphocytes. It binds to three different receptors, BCMA, TACI, and BAFF-R, which are all members of the family of TNF receptors. Defects in the genes encoding BAFF or BAFF-R abolish the generation of mature B cells," scientists in Switzerland report.
"BAFF is made by myeloid cells, whereas BAFF-R is expressed preferentially on B cells. BAFF induces polyclonal maturation of resting, short lived, immature B cells into resting, long-lived, mature B cells, without proliferation. Lupus-prone mice have elevated blood levels of BAFF, and treatment of these mice with the BAFF decoy receptor (BCMA-Ig) prevents the onset of this systemic autoimmune disease," wrote F. Melchers and colleagues from the University of Basel.
The researchers concluded: "Human lupus ...
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Source: HighBeam Research, BAFF overexpression in lupus may be blockable with decoy receptor,...