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Safer smallpox vaccination regimen modeled for HIV-1-infected patients.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Scientists have modeled a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques.
According to a study from an international team of researchers, "We have modeled smallpox vaccination with Dryvax (Wyeth) in rhesus macaques that had depletion of CD4+ T cells induced by infection with simian immunodeficiency virus or simian/human immunodeficiency virus. Smallpox vaccination induced significantly larger skin lesions in immunocompromised macaques than in healthy macaques. Unexpectedly, 'progressive vaccinia' was infrequent."
"Vaccination of immunocompromised macaques with the genetically-engineered, replication-deficient poxvirus NYVAC, before or after retrovirus infection, was safe and lessened the severity of Dryvax-induced skin lesions," stated Yvette Edghill-Smith at the National Cancer Institute in the United States and collaborators around the world. "Neutralizing antibodies to vaccinia were induced by NYVAC, even in macaques with severe CD4+ T cell depletion, and their titers inversely correlated with the time to complete resolution of the skin lesions."
"Together, these ...
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- Newspaper article from: Morbidity and Mortality Weekly Report February 7, 2003 700+ words
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- Magazine article from: American Journal of Infectious Diseases Nishiura, Hiroshi Arita, Isao Schwehm, Markus Eichner, Martin January 1, 2006 700+ words
...assessment of the protective effects of smallpox vaccination, with particular emphasis on the...theoretical points of view. Although smallpox vaccination has the longest history of all vaccinations...evaluation of the effectiveness of smallpox vaccination (e.g., a randomized ...
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- Magazine article from: Emerging Infectious Diseases Upfal, Mark J. Cinti, Sandro May 1, 2004 700+ words
...administered during the National Smallpox Vaccination Program (NSVP) in 2003 has received...Cardiac deaths after a mass smallpox vaccination campaign--New York City, 1947...2003 might have been unrelated to smallpox vaccination." While the causes of these cardiac...
- Smallpox vaccination: Is your plan in place?
- Newspaper article from: Occupational Health Management April 1, 2003 700+ words
Smallpox vaccination: Is your plan in place? With...American Health Consultants offers Smallpox Vaccination of Health Care Workers: The...beginning or are expanding your smallpox vaccination program, this audio conference...
- Contraindications to Smallpox Vaccination.
- Newspaper article from: Hospital Employee Health December 1, 2002 700+ words
Contraindications to Smallpox Vaccination Eczema/atopic dermatitis...vaccinia necrosum following smallpox vaccination. Therefore, smallpox...mandatory HIV testing prior to smallpox vaccination, but recommends that HIV...
Source: HighBeam Research, Safer smallpox vaccination regimen modeled for HIV-1-infected...