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E1-deleted adenoviral vaccine carriers induce antibody responses.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Mucosally delivered E1-deleted adenoviral vaccine carriers induce transgene product-specific antibody responses in neonatal mice.
"E1-deleted adenoviral vectors of the human serotype 5 (AdHu5) and the chimpanzee serotype 68 (AdC68) expressing the rabies virus glycoprotein (rab.gp) were tested for induction of transgene product-specific antibodies upon intranasal or oral immunization of newborn mice," scientists writing in the Journal of Immunology report.
"Both vectors induced antibodies to rabies virus that could be detected in serum and from mucosal secretions," said Zhiquan Xiang and colleagues at the University of Pennsylvania. "Serum rabies virus neutralizing antibody titers sufficed to protect neonatally vaccinated mice against a subsequent challenge with rabies virus. The efficacy of the AdHu5rab.gp vector given orally to newborn mice born to AdHu5 virus-immune dams was not impaired by maternally transferred antibodies to the ...
- Live vaccinia-rabies virus recombinants protect against rabies.
- Newspaper article from: Obesity, Fitness & Wellness Week December 4, 2004 700+ words
...NewsRx.net) -- Live vaccinia-rabies virus recombinants, but not an inactivated rabies virus cell culture vaccine, protect B-lymphocyte...animals consist of the five inactivated rabies virus proteins. The vaccines elicit a CD4...
- Genetic suppressor elements offer a new approach for treating rabies virus.
- Newspaper article from: Drug Week October 8, 2004 700+ words
...elements offer a new approach for treating rabies virus. "A cDNA library of short random fragments...derived from four of the five genes of the rabies virus genome has been used to isolate genetic...expressed intracellularly that inhibit rabies virus replication," according to ...
- New findings from Institute Pasteur describe advances in rabies virus cell...
- Newspaper article from: Virus Weekly November 10, 2009 700+ words
Fresh data on rabies virus are presented in the report 'A novel animal-component-free medium for rabies virus production in Vero cells grown on...work. Kinetics of cell growth and rabies virus (strain LP 2061) production were...
- Rabies Virus-Based Vaccine Against HIV Created; Other Viruses Next.(Brief...
- Newspaper article from: AIDS Weekly March 20, 2000 700+ words
...an HIV vaccine using a weakened rabies virus to carry a piece of the HIV "coat...Academy of Sciences. Using the rabies virus as a vehicle for a vaccine is novel, says Pomerantz. "The rabies virus is the vehicle to get an HIV envelope...
- Rabies Virus-Based Vaccine Against HIV Created; Other Viruses Next.
- Newspaper article from: Vaccine Weekly March 22, 2000 700+ words
...an HIV vaccine using a weakened rabies virus to carry a piece of the HIV "coat...Academy of Sciences. Using the rabies virus as a vehicle for a vaccine is novel, says Pomerantz. "The rabies virus is the vehicle to get an HIV envelope...
- Rabies Virus Vectors Induce T-Cell Response.
- Newspaper article from: Gene Therapy Weekly April 26, 2001 700+ words
...medical writer - HIV vectors based on the rabies virus induce robust T-cell responses, suggesting...al. found that vectors based on the rabies virus provoke just such a response in mice...and heterologous strains of HIV ("Rabies virus-based vectors expressing human immunodeficiency...
- Rabies Virus Vectors Induce T-Cell Response.(Brief Article)
- Newspaper article from: Vaccine Weekly April 25, 2001 700+ words
...medical writer - HIV vectors based on the rabies virus induce robust T-cell responses, suggesting...al. found that vectors based on the rabies virus provoke just such a response in mice...and heterologous strains of HIV ("Rabies virus-based vectors expressing human immunodeficiency...
- Findings from Y.Z. Zhang and co-authors provide new insights into rabies virus.
- Newspaper article from: Virus Weekly August 12, 2008 700+ words
...healthy animals are potential carriers of rabies virus in China, 153 domestic dogs were collected...for 6 months. Initially, findings of rabies virus antigen in the saliva of 15 dogs by...the ELISA test alone, detection of rabies virus antigen in saliva of some animals was...