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Changes in mumps virus gene sequence linked to phenotype variability.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Changes in mumps virus gene sequence is associated with variability in neurovirulent phenotype.
"Mumps virus is highly neurotropic and, prior to widespread vaccination programs, was the major cause of viral meningitis in the United States. Nonetheless, the genetic basis of mumps virus neurotropism and neurovirulence was until recently not understood, largely due to the lack of an animal model," scientists writing in the Journal of Virology report.
"Here, nonneurovirulent (Jeryl Lynn vaccine) and highly neurovirulent (88-1961 wild type) mumps virus strains were passaged in human neural cells or in chicken fibroblast cells with the goal of neuroadapting or neuroattenuating the viruses, respectively," said Steven A. Rubin and collaborators at the Food and Drug Administration and Johns Hopkins University in the United States. "When tested in our rat neurovirulence assay against the respective parental strains, a Jeryl Lynn virus variant with an enhanced propensity for replication (neurotropism) and damage (neurovirulence) in the brain and an 88-1961 wild-type virus variant with decreased neurotropic and neurovirulent properties were recovered."
"To determine the molecular basis for the observed differences in neurovirulence and neuroattenuation, the complete genomes of the parental ...
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...targeting the matrix protein gene of mumps virus were designed by using our oligo...laboratory isolated and one Jeryl Lynn strain) of mumps virus. The suggested TaqMan-based...laboratory-isolated strains and one Jeryl Lynn strain," investigators in...
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- Mumps virus' V protein disrupts alpha interferon receptor complex.
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- Newspaper article from: Virus Weekly January 27, 2004 700+ words
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