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G protein coupled receptors allow manipulation of inflammation in vivo.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Targeting of G protein coupled receptors may allow management of inflammation in vivo using synthetic and natural ligands.
"Cyclic AMP elevating Gs protein coupled receptors were considered for a long time to be immunosuppressive. One of these receptors, adenosine A[subscript]2A receptor, was implicated in a physiological mechanism that down regulates inflammation and protects tissues from excessive immune mediated damage. Targeting of these receptors by selective agonists may lead to better protocols of anti-inflammatory treatments," scientists in the United States report.
"At the same time inhibiting the Gs protein coupled mediated signaling with antagonists could be explored in studies of approaches to enhance inflammation and tissue damage," stated J. F. Kinsel and M. V. Sitkovsky at the National Institute of Allergy and Infectious Diseases. "Enhancement of targeted tissue damage is highly desirable when it is cancerous tissue, while enhancement of inflammatory events ...
- OSI Pharmaceuticals licenses Cyanamid's yeast Gpcr technology in patent...
- Newspaper article from: BIOTECH Patent News January 1, 2000 700+ words
...of targets in yeast, including G-protein coupled receptors, hybrid G-protein coupled receptors and orphan receptors for use in human therapeutics. G-protein coupled receptors are an important class of targets...
- G Protein-Coupled Receptors: Molecular Pharmacology Offers A Unique View Of...
- Press release article from: M2 Presswire November 22, 2007 700+ words
...Research and Markets: G Protein-Coupled Receptors: Molecular Pharmacology...announced the addition of "G Protein-coupled Receptors: Molecular Pharmacology" to their offering G protein-coupled receptors (GPCRs) are membrane...
- G Protein Coupled Receptors Molecular Pharmacology Offers a Unique View of...
- Press release article from: Business Wire November 22, 2007 700+ words
...announced the addition of "G Protein-coupled Receptors: Molecular Pharmacology" to their offering. G protein-coupled receptors (GPCRs) are membrane...directly or indirectly. G Protein-coupled Receptors: Molecular Pharmacology...
- Publication No. EP2093293 Published on Aug. 26, Assigned to Incyte for...
- News wire article from: US Fed News Service, Including US State News September 9, 2009 700+ words
...have developed a G-protein coupled receptors. The patent has been...invention provides human G-protein coupled receptors and polynucleotides which identify and encode G-protein coupled receptors. The invention also provides...
- Research and Markets : Technical overview of G-Protein Coupled Receptors...
- Press release article from: M2 Presswire March 14, 2005 700+ words
...Technical overview of G-Protein Coupled Receptors (GPCRs): Emerging technologies...announced the addition of G-Protein Coupled Receptors (GPCRs): Technical...Edition to their offering G Protein-Coupled Receptors (GPCRs) account for...
- Research and Markets: G-Protein Coupled Receptors - GPCRs: Technical Overview,...
- Press release article from: Business Wire June 15, 2005 700+ words
...c19266) has announced the addition of G-Protein Coupled Receptors (GPCRs): Technical Overview, Emerging Technologies...Opportunities, 2nd Edition to their offering. G Protein-Coupled Receptors (GPCRs) account for 50% of the current drug...
- G protein coupled receptors allow manipulation of inflammation in vivo.
- Newspaper article from: Health & Medicine Week December 8, 2003 700+ words
...net) -- Targeting of G protein coupled receptors may allow management of...Cyclic AMP elevating Gs protein coupled receptors were considered for a...Possible targeting of G protein coupled receptors to manipulate inflammation...
- Green-fluorescent-protein-based assay characterizes G-protein-coupled receptors.
- Newspaper article from: Biotech Week October 20, 2004 700+ words
...assay characterizes G-protein-coupled receptors. According to published...and pharmacology of G-protein-coupled receptors in mammalian cells is...with appropriate G-protein-coupled receptors and subsequent activation...
