AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Human cytomegalovirus pp65 protein acts as an inhibitor of interferon response.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Human cytomegalovirus pp65 protein acts as an inhibitor of interferon response, can block antiviral activity.
"The initial interaction of human cytomegalovirus with fibroblasts triggers, and then partially blocks, an innate immune response pathway that leads to the induction of IFN-responsive genes and proinflammatory chemokines. Infection of fibroblasts with human cytomegalovirus inhibited their ability to respond to exogenous IFN," scientists in the United States report.
"Consistent with the observation that the block did not depend on de novo viral protein synthesis, ectopic expression of the viral UL83-coded pp65, an abundant virion protein, inhibited IFN signaling. Furthermore, DNA array analysis showed that infection with a pp65-deficient mutant virus caused a much stronger induction of many IFN-response and proinflammatory chemokine RNAs than infection with wild-type virus.
"The nuclear DNA-binding activities of transcription factors NF-kappaB and IRF1 were induced to a much greater extent after infection with the pp65-deficient mutant than with wild-type virus. IFN-stimulated gene factor 3 DNA-binding was modestly enhanced, whereas IRF3 activity was not affected by mutation ...
- Human cytomegalovirus coding potential reevaluated.
- Newspaper article from: Virus Weekly January 13, 2004 700+ words
...potential of human cytomegalovirus has been...Proceedings of the National Academy of Sciences...isolate of human cytomegalovirus." Murphy...Proceedings of the National Academy of Sciences...Reevaluation of human cytomegalovirus coding potential...
- Human herpesvirus 7 is a T-lymphotropic virus and is related to, but...
- Newspaper article from: AIDS Weekly November 30, 1992 700+ words
...SOURCE: Proceedings of the National Academy of Sciences, November...distinct from HHV-6 and human cytomegalovirus (CMV), DNA sequencing...identity with HHV-6 and human cytomegalovirus of 57.5 percent and...
- Human cytomegalovirus large terminase subunit pUL56 characterized.
- Newspaper article from: Drug Week July 2, 2004 700+ words
...characterized the structure of human cytomegalovirus large terminase subunit pUL56...large terminase subunit pUL56 of human cytomegalovirus, a highly pathogenic virus, to...Insights into the structure of human cytomegalovirus large terminase subunit pUL56...
- Link to human cytomegalovirus seen.(Brief Article)
- Newspaper article from: Cancer Weekly December 10, 2002 700+ words
...cause or genetic predisposition. Human cytomegalovirus (CMV) is a widespread virus that...of colorectal cancer samples. "Human cytomegalovirus nucleic acids and proteins can...further studies to establish whether human cytomegalovirus participates in pathogenesis of...
- HIV-1 and HHV-6 antigens and transcripts in retinas of patients with AIDS in...
- Newspaper article from: AIDS Weekly Qavi, H.B. Green, M.T. Lewis, D.E. Hollinger, F.B. Pearson, G. Ablashi, D.V. October 16, 1995 700+ words
...Patients with AIDS in the Absence of Human Cytomegalovirus." Investigative Ophthalmology...human herpesvirus (HHV)-6, and human cytomegalovirus (HCMV) in retinas of patients...positive for HHV-6 antigens. Human cytomegalovirus antigens were not detectable in...
- Human cytomegalovirus genomes highly divergent.(Brief Article)
- Newspaper article from: Vaccine Weekly February 5, 2003 700+ words
...study from Italy, "The low-passage Toledo strain of human cytomegalovirus (HCMV) and fresh clinical HCMV isolates have been reported...cell-tropic variant and the parental Toledo strain of human cytomegalovirus are highly divergent. J Med Virol, 2003;69(1...
- Human cytomegalovirus genomes highly divergent.
- Newspaper article from: Virus Weekly February 4, 2003 700+ words
...study from Italy, "The low-passage Toledo strain of human cytomegalovirus (HCMV) and fresh clinical HCMV isolates have been reported...cell-tropic variant and the parental Toledo strain of human cytomegalovirus are highly divergent. J Med Virol, 2003;69(1...
- Systematic sclerosis following human cytomegalovirus infection. (Letters).
- Magazine article from: Annals of the Rheumatic Diseases Ferri, C Cazzato, M Giuggioli, D Sebastiani, M Magro, C October 1, 2002 700+ words
...possible triggering factors. (3-6) Among these, human cytomegalovirus (HCMV) infection may play a part in the pathogenesis...ANoA, anti-nucleolar antibodies; HCMV (ISH), human cytomegalovirus detected in the skin biopsy by in situ hybridisation...
- Committee for Orphan Medicinal Products public summary of positive opinion for...
- News wire article from: Chemical Business Newsbase January 27, 2009 700+ words
...European Commission to Biotest Pharma GmbH, Germany, for human cytomegalovirus immunoglobulin for the prevention of congenital cytomegalovirus...summary of positive opinion for orphan designation of human cytomegalovirus immunoglobulin for the prevention of congenital cytomegalovirus...
- Human cytomegalovirus interaction with platelets and adhesive glycoproteins:...
- Newspaper article from: AIDS Weekly Agbanyo, F.R. Wasi, S. December 12, 1994 700+ words
According to the authors' abstract of an article published in the Journal of Infectious Diseases, "Human cytomegalovirus (HCMV) is released into plasma during active infection. To characterize cell-free virus interaction with blood components...
Source: HighBeam Research, Human cytomegalovirus pp65 protein acts as an inhibitor of interferon...