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Microarray profiling of antibody responses against SHIV developed.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method of microarray profiling of antibody responses against simian-human immunodeficiency virus (SHIV).
According to a study from the United States, "We developed antigen microarrays to profile the breadth, strength, and kinetics of epitope-specific antiviral antibody responses in vaccine trials with a simian-human immunodeficiency virus (SHIV) model for human immunodeficiency virus (HIV) infection. These arrays contained 430 distinct proteins and overlapping peptides spanning the SHIV proteome."
"In macaques vaccinated with three different DNA and/or recombinant modified vaccinia virus Ankara (rMVA) vaccines encoding Gag-Pol or Gag-Pol-Env, these arrays distinguished vaccinated from challenged macaques, identified three novel viral epitopes, and predicted survival," reported Henry E. Neuman de Vegvar and collaborators at Stanford and Emory Universities. "Following viral challenge, anti-SHIV antibody responses ultimately converged to target eight immunodominant B-cell regions in Env regardless of vaccine regimen, host histocompatibility type, and divergent T-cell specificities. After challenge, responses to ...
- Analysis of murine antibody responses to baculovirus-expressed human...
- Newspaper article from: AIDS Weekly Bristow, R.G.W. Douglas, A.R. Skehel, J.J. Daniels, R.S. September 26, 1994 700+ words
...based cytocidicity assay was used and shown to be an effective and objective method for the screening of human immunodeficiency virus (HIV)-neutralizing activity in large numbers of samples. None of the MAbs chara cterized in this...
- Antibody responses to Haemophilus influenzae type b and Streptococcus...
- Newspaper article from: AIDS Weekly Gibb, D. Spoulou, V. Giacomelli, A. Griffiths, H. Masters, J. Misbah, S. Nokes, L. Pagliaro, A. Giaquinto, C. Kroll, S. Goldblatt, D. March 27, 1995 700+ words
...Infectious Disease Journal, "Antibody responses to Haemophilus influenzae type...than 18 months of age, born to human immunodeficiency virus-positive mothers. Preimmunization...counts. These data suggest that human immunodeficiency virus-infected children should...
- The immunogenicity of haemophilus influenzae type b conjugate (HbOC) vaccine in...
- Newspaper article from: AIDS Weekly Kale, K.L. King, J.C. Farley, J.J. Vink, P.E. Cimino, C.O. Paradiso, P.R. June 26, 1995 700+ words
...HbOC) Vaccine in Human Immunodeficiency Virus-Infected...phosphate (PRP) antibody responses to Haemophilus...compared in 23 human immunodeficiency virus (HIV...conclude that antibody responses to HbOC vaccine...
- Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein...
- Newspaper article from: AIDS Weekly Earl, P.L. Broder, C.C. Long, D. Lee, S.A. Peterson, J. Chakrabarti, S. Doms, R.W. Moss, B. June 13, 1994 700+ words
...Virology, "We synthesized and purified a recombinant human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein...HIV-1 Env glycoproteins to analyze the repertoire of antibody responses to the tertiary and quaternary structure of the protein...
- Direct injection of a recombinant retroviral vector induces human...
- Newspaper article from: AIDS Weekly Irwin, M.J. Laube, L.S. Lee, V. Austin, M. Chada, S. Anderson, C.G. Townsend, K. Jolly, D.J. Warner, J.F. September 12, 1994 700+ words
...nonreplicating recombinant retroviral vector, encoding the human immunodeficiency virus type 1 (HIV-1) IIIB envelope and rev proteins...The vector also elicited HIV-1 envelope-specific antibody responses in mice and baboons. These studies demonstrate the ability...
- Immunization with a soluble CD4-gp120 complex preferentially induces...
- Newspaper article from: AIDS Weekly Kang, C.Y. Hariharan, K. Nara, P.L. Sodroski, J. Moore, J.P. October 10, 1994 700+ words
...b e critical for the development of any gp120-based human immunodeficiency virus type 1 (HIV-1) vacci ne. It was hypothesized...mice for its ability to induce neutralizing anti-gp120 antibody responses. Seventeen mon oclonal antibodies (MAbs) were generated...
- Multibranched peptide constructs derived from the V3 loop of envelope...
- Newspaper article from: AIDS Weekly Benjouad, A. Chapuis, F. Fenouillet, E. Gluckman, J.-C. April 17, 1995 700+ words
...in Toulon, France, "The V3 loop of the gp120 of human immunodeficiency virus type 1 (HIV-1) is assumed to be involved in...HIV-1 positive sera. Only MBPC2 elicited significant antibody responses in rabbits. The V3-derived MBPCs bound to CD4...
- The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV)...
- Newspaper article from: AIDS Weekly February 18, 1991 700+ words
...vaccine trial. Although there was a high frequency of serum antibody responses after three doses of the vaccine (30 of 33 subjects...was seen in our study." While only low-intensity antibody responses occurred in 30 of the 33 subjects who completed a three...
- Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in...
- Newspaper article from: AIDS Weekly November 25, 1991 700+ words
...for the development of a polyvalent mixture of HIV env gp120 V3 region synthetic peptides capable of inducing antibody responses that neutralize HIV field isolates," Hart et al. write. "However, major problems remain for the development...
- Vaccination of vaccinia-naive adults with human immunodeficiency virus type-1...
- Newspaper article from: AIDS Weekly August 31, 1992 700+ words
...and controls. "Of 22 HIVAC-1e recipients with lesion formation, 16 developed low-titer gp160-specific antibody responses detectable by Western blot," Graham et al. report. "The peak response occurred between days 70 and 120 and...
Source: HighBeam Research, Microarray profiling of antibody responses against SHIV developed.