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Early SHIV control in monkeys causes long-lasting asymptomatic outcomes.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus (SHIV) chimeric virus infections in rhesus monkeys usually results in long-lasting asymptomatic clinical outcomes.
"In contrast to simian immunodeficiency viruses (SIVs), which induce immunodeficiency over a one- to two-year period, highly pathogenic simian-human immunodeficiency viruses (SHIVs) cause an irreversible and systemic depletion of CD4+ T lymphocytes in macaque monkeys within weeks of inoculation. Nonetheless, the seemingly more aggressive SHIVs have proven to be easier to control by the same vaccine regimens that fail to contain SIV," scientists in the United States report.
"Because early events during in vivo infections may determine both the pathogenic consequences of the challenge virus and its sensitivity to interventions that prevent disease, we have evaluated the effects of inoculum size and a potent antiretroviral drug on the development of disease in monkeys infected with SHIVDH12R," stated Tatsuhiko Igarashi and colleagues at the National Institute of Allergy and Infectious Diseases and Cornell University.
"The results obtained show that in a majority of ...
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Source: HighBeam Research, Early SHIV control in monkeys causes long-lasting asymptomatic...