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Jet injection is amenable to administering adeno-associated virus vector.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Jet injection is amenable to administering adeno-associated virus vector.
According to a study from Czech Republic, "the jet-injection technology was used for delivery of recombinant adeno-associated virus (rAAV). Although AAV-based vectors are an attractive tool in gene therapy, some methodological and technical problems of their targeted delivery remain to be solved. We tried to address some of these cell-targeting problems by using a new low-volume needleless injection device, the Swiss Injector."
"First, we tested by electron microscopy whether jet-injection would have any detrimental effect on rAAV particle integrity. Second, we compared transgene expression after infection of 293T cells with fired or control (non-fired) rAAV that expressed the green fluorescent protein (GFP), beta-galactosidase (beta-gal), the B7.1 molecule, and interleukin 2 (IL2). Third, an rAAV carrying the genes coding for beta-gal was jet-injected into mouse subcutaneous (s.c.) tumors," described O. Janouskova and colleagues, Institute of Hematology and Blood Transfusion, Prague.
"The staining of tumor cryosections revealed beta-gal ...
- Jet injection is amenable to administering adeno-associated virus vector.
- Newspaper article from: Drug Week December 12, 2003 700+ words
...their study in International Journal of Molecular Medicine...recombinant adeno-associated virus by jet injection...information for the International Journal of Molecular Medicine...areas of Adeno-Associated Virus, Gene Therapy...
- Avigen licenses adeno-associated virus vector technology to Stratagene.(Brief...
- Newspaper article from: BIOTECH Patent News July 1, 2000 700+ words
...s proprietary recombinant adeno-associated virus vectors for research purposes. Stratagene...royalties on sales of the adeno-associated virus kits and other products developed...research tools, using Avigen's adeno-associated virus technology. In addition, Avigen...
- Adeno-Associated Virus Vectors Are Preferred For Myocardial Transfection.
- Newspaper article from: Gene Therapy Weekly July 12, 2001 700+ words
...tissues, researchers found adeno-associated virus vectors to be the most effective...adenovirus, recombinant adeno-associated virus, and (ICP27-) herpes simplex virus...were comparable with that of adeno-associated virus after 21 days. Intense immune responses...
- Viscous solutions propel adeno-associated virus vectors to the diaphragm.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...Viscous solutions propel adeno-associated virus vectors to the diaphragm. According...for delivery of recombinant adeno-associated virus (rAAV) vectors to the mouse diaphragm...diaphragm using recombinant adeno-associated virus vectors," researchers indicated...
- New techniques purify adeno-associated virus type 5 with less work.
- Newspaper article from: Gene Therapy Weekly February 5, 2004 700+ words
...New techniques purify adeno-associated virus type 5 with less work. According...viral vectors derived from adeno-associated virus (AAV) are rapidly becoming the vehicles...applications. AAV-2 is the adeno-associated virus serotype most commonly employed in...
- Adeno-associated virus 1 transduces both white and gray matter in the brain.
- Newspaper article from: Health & Medicine Week November 10, 2003 700+ words
...NewsRx.net) -- Adeno-associated virus 1 transduces both white and...matter in the brain. "Adeno-associated virus (AAV) vectors are capable...study in Gene Therapy (Adeno-associated virus vector-mediated transduction...
- Adeno-associated virus looks promising for different cardiac gene therapies.
- Newspaper article from: Genomics & Genetics Weekly November 7, 2003 700+ words
...amp; NewsRx.net) -- Adeno-associated virus looks promising for different cardiac...vector systems. Here we used adeno-associated virus (AAV) vectors to deliver either...sarcoglycan-deficiency hamster by adeno-associated virus-2 vectors. Gene Therapy, 2003...
- Adeno-associated virus disseminates genes into the central nervous system.
- Newspaper article from: Pain & Central Nervous System Week May 12, 2003 700+ words
...amp; NewsRx.net) -- Adeno-associated virus disseminates genes into the central...have used recombinant type 2 adeno-associated virus to deliver the gene encoding green...gene transfer by recombinant adeno-associated virus could be used as a tool to investigate...
