AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
MAGE-4 peptide recognized by cytolytic T lymphocytes on tumor cells.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- A new MAGE-4 antigenic peptide is recognized by cytolytic T lymphocytes on HLA-A1 tumor cells.
"'Cancer-germline' genes such as those of the MAGE family are expressed in many tumors and in male germline cells, but are silent in other normal tissues. They encode shared tumor-specific antigens, which have been used in small therapeutic vaccination trials of cancer patients. Gene MAGE-4, which is expressed in more than 50% of carcinomas of esophagus, head and neck, lung, and bladder, has two known alleles," scientists in Belgium report.
"Using PCR amplifications and digestions of the amplified product, we found that one third of the MAGE-4-positive samples expressed MAGE-4a," said T. Kobayashi and colleagues at the University of Louvain. "We folded HLA-A1 tetramers with peptide MAGE-4a[subscript]169-177 EVDPASNTY, which is homologous to MAGE-1- and MAGE-3-encoded peptides recognized on HLA-A1 by cytolytic T lymphocytes. Blood lymphocytes from an individual without cancer were directly labeled with these A1/MAGE-4 tetramers. The very rare cells that were stained were sorted by flow cytometry and ...
- MAGE-4 peptide recognized by cytolytic T lymphocytes on tumor cells.
- Newspaper article from: Proteomics Weekly December 8, 2003 700+ words
...lymphocytes on HLA-A1 tumor cells. "'Cancer-germline' genes such as those of the MAGE family are expressed in...specifically cells pulsed with this MAGE-4 peptide and HLA-A1 tumor cells expressing MAGE-4a, demonstrating that...
- MAGE-A1-expressing tumor cell 5' region less methylated than other parts of...
- Newspaper article from: Biotech Week August 4, 2004 700+ words
...The 5' region of MAGE-A1-expressing tumor cells are less methylated than...tumorigenesis. "We show that in tumor cells expressing MAGE-A1, the 5' region...specific hypomethylation of MAGE-A1 in tumor cells relies on a transient...
- MAGE-1 peptide recognized by T cells on HLA-B*5701 tumors identified.
- Newspaper article from: Immunotherapy Weekly August 11, 2004 700+ words
...to position 102-112 of the MAGE-1 protein sequence, is ITYKVADLVGF...in Belgium and Italy. "When tumor cells expressing MAGE-1 were transfected with HLA...that the peptide is processed in tumor cells and can, therefore, be used...
- New antigenic peptide encoded by several MAGE genes identified.
- Newspaper article from: Cancer Weekly April 27, 2004 700+ words
...corresponds to position 212-220 of MAGE-2, -3, -6, and -12...lines expressing one of these MAGE genes were lysed by the CTL...is efficiently processed in tumor cells and can therefore be used as...peptide is encoded by several MAGE genes." Breckpot and associates...
- Rhabdomyosarcomas potential target of MAGE-specific immunotherapies.
- Newspaper article from: Cancer Weekly July 27, 2004 700+ words
...lines to process and present the MAGE-A tumor antigens to effectors...investigated recognition of MAGE-A-positive rhabdomyosarcoma...restricted T cells specific for a MAGE-A-derived peptide," scientists...impaired recognition of the tumor cells. Therefore, to obtain HLA...
- Mutations of the beta(2)-microglobulin Gene Result in a Lack of HLA Class I...
- Newspaper article from: Vaccine Weekly February 8, 1999 700+ words
...Patients Immunized with MAGE Peptides." Tissue Antigens...microglobulin gene of tumor cells of two metastatic melanoma...received immunizations with MAGE peptides. One mutation...on the surface of the tumor cells. This may explain why...
- Mages' love of sports = help for needy
- Newspaper article from: Chicago Sun-Times Tom Sheridan December 4, 1987 700+ words
...probably won't remember. But it's doubtful Morrie Mages will ever forget. Mages, long Chicago's sporting goods czar, sold his chain of stores recently. That doesn't mean Mages, 71, will keep his hand out of two subjects he...
- MAGE Gene May Be Immunotherapy Target for Hepatocellular Carcinoma.(Brief...
- Newspaper article from: Vaccine Weekly January 12, 2000 700+ words
2000 JAN 12 - (NewsRx.com) -- The MAGE-1 gene is expressed with high frequency...indicate the this gene, and perhaps other MAGE genes, may be potential targets for HCC...the tumor rejection antigen encoded by MAGE-1 might be a candidate target for HCC...