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Histone H1 antigen protects against cutaneous leishmaniasis in monkeys.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- A recombinant histone H1 antigen provided protection against cutaneous leishmaniasis in outbred vervet monkeys.
"Infection with Leishmania major parasites results in the development of cutaneous ulcerative lesions on the skin. We investigated the protective potential of a single, recombinant histone H1 antigen against cutaneous leishmaniasis in an outbred population of vervet monkeys, using Montanide adjuvant. Protection was assessed by challenging the animals with a mixture of vector sand fly salivary-gland lysate and a low dose of in vitro derived parasites, thus more closely mimicking natural infection induced by L. major," investigators in Switzerland report.
"The course of infection in immunized monkeys was compared with that of animals that had healed from a primary infection and were immune," said Slavica Masina and collaborators at the University of Lausanne and Dictagene in Switzerland and the Institute of Primate Research in Kenya. "The monkeys immunized with recombinant histone H1 showed ...
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Source: HighBeam Research, Histone H1 antigen protects against cutaneous leishmaniasis in...