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Genetic immunization using pDNA-coated nanoparticles detailed.
2003 DEC 10 - (NewsRx.com & NewsRx.net) -- Detailed methodology on genetic immunization by jet injection of targeted pDNA-coated nanoparticles has been published in a recent issue of the journal Methods.
"Genetic immunization strategies have largely focused on the use of 'naked' plasmid DNA or the gene gun. However, there remains a clear need to further improve the efficiency and/or cost of potential DNA vaccines. The theoretical basis of our research is to rationally design genetic immunization methodologies for nanoparticle-based delivery systems of plasmid DNA, perhaps in combination with already commercially available needle-free devices, such as the Biojector 2000," scientists in the United States report.
"These methodologies may both reduce the dose of pDNA required and enhance the breadth and depth of protective immune responses (i.e., humoral and cellular)," said Russell J. Mumper and Zhengrong Cui at the University of Kentucky. "The purpose of this article is to provide detailed experimental methods to engineer and characterize pDNA-coated cationic nanoparticles ...
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...processes or products would be surface engineered, or coated, nanoparticles and/or dispersions of nanoparticles in water or solvents...delivers commercial quantity and quality nanoparticles, coated nanoparticles, and nanoparticle dispersions in a variety of media...
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Source: HighBeam Research, Genetic immunization using pDNA-coated nanoparticles detailed.