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PTEN overexpression squashes the migration of ovarian cancer cells.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- PTEN overexpression squashes the migration of ovarian cancer cells.
"Peritoneal dissemination is the major progression pathway of ovarian cancer, and its control is important for improvement of the prognosis. PTEN is a tumor suppressor gene, and is known to inhibit cancer cell growth and migration. To investigate the possibility of gene therapy using PTEN for ovarian cancer, we introduced PTEN cDNA into an ovarian cancer cell line HRA carrying wild-type PTEN, and examined the effects in vitro and in vivo," scientists in Japan report.
"Using PTEN cDNA cloned from a human liver cDNA library, a PTEN expression vector was constructed. This vector was introduced into HRA cells by the standard calcium phosphate precipitation method, and an HRA cell line overexpressing PTEN (HRA/PTEN) was established. On the cell migration test by in vitro scratch wound healing assay, the number of migrating cells was 6.3[+ or -]0.9 cells/mm[superscript]2 in HRA/PTEN, which was significantly smaller than that in the control (39.7[+ or -]3.2 cells/mm[superscript]2) (p
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Source: HighBeam Research, PTEN overexpression squashes the migration of ovarian cancer cells.