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Sex differences exist in effect of obesity on serum gonadotropin levels.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- Sex differences exist in the effect of obesity on 24-hour mean serum gonadotropin levels.
"To determine the effect of obesity on serum gonadotropin levels and any possible sex difference in the effect, we measured the 24-hour mean serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) concentrations in 62 healthy men with Body Mass Index (BMI) ranging from 20-94 and 61 healthy, regularly cycling women with BMIs ranging from 19-76. We also measured free testosterone (T) and estradiol (E2) in these subjects," scientists in the United States report.
"There was a significant negative correlation between serum FSH and BMI in men: FSH(IU/L)=49.9 x BMI-0.567; r=-0.376, p=0.0026; but a significant positive correlation between serum FSH and BMI in women: FSH(IU/L)=7.66 [+ or -] 0.071 x BMI; r=0.302, p=0.018," stated Gladys W. Strain and collaborators at Beth Israel Medical Center, Mount Sinai Medical Center, and St. Luke's-Roosevelt Medical Center in New York. "Serum LH was weight-invariant in both sexes. In men, free T was negatively correlated with BMI: Free T(nmol/L)= 0.74-0.0068 x BMI; r=0.585, p=0.0381; and free E2 was positively correlated with BMI: Free E2(pmol/L)=-1.03[+ or -]0.057 x BMI; r=0.50, p=0.0014."
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