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2003 DEC 4 - (NewsRx.com & NewsRx.net) -- A new swine uterus perfusion system should advance physiological research.
"The objective of this study was to establish an experimental model for extracorporeal perfusion of swine uterus. In order to validate this model, we examined some biochemical parameters and determined the effect of oxytocic drugs (Oxytoxin, Prostaglandin E-2) on extracorporeal perfused swine uteri. Thirty swine uteri were perfused with Krebs-Ringer bicarbonate-glucose buffer for a period up to eleven hours with the aim to preserve a viable organ, which should be responsive to hormones," researchers in Germany explained.
"The intrauterine pressure was recorded after administration of various concentrations of oxytocin and prostaglandin E-2. Perfusate pH, perfusate lactate, partial oxygen and carbon dioxide tensions, oxygen saturation, and hydrogencarbonate levels in the perfusate, all indicators of tissue ischemia or cell necrosis, showed good preservation of the organ for up to seven hours," R. Dittrich and colleagues, University of Erlangen-Nuremberg, Department of Obstetrics and Gynecology said.
"We examined the relation of intrauterine ...