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KCl cotransport is an important modulator of cervical cancer growth and invasion.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- KCl cotransport is an important modulator of cervical cancer growth and invasion. According to a study from Taiwan, "Cervical cancer is a major world health problem for women, but the pathophysiology of this disease has received scant attention.
"Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and cellular osmotic homeostasis. Functional assays of KCl cotransport activation by osmotic swelling, staurosporine, and N-ethylmaleimide indicate that removal of the N-terminal 117 amino acids from KCC1 produces a dominant-negative loss-of-function phenotype for KCl cotransport in human cervical cancer cells," wrote M.R. Shen and colleagues, National Cheng Kung University College of Medicine
"The capability for regulatory volume decrease is much attenuated in the loss-of-function KCC mutant cervical cancer cells. The loss-of-function KCC mutant cervical cancer cells exhibit inhibited cell growth accompanied by decreased activity of the cell cycle gene products retinoblastoma and cdc2 kinase," the researchers wrote.
"Reduced ...
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Source: HighBeam Research, KCl cotransport is an important modulator of cervical cancer growth...